Ψ-2C-T-4
| Clinical data | |
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| Other names | psi-2C-T-4; 4-Isopropylthio-2,6-dimethoxyphenethylamine; 2,6-Dimethoxy-4-isopropylthiophenethylamine |
| Routes of administration | Oral[1][2][3][4] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
| ATC code |
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| Pharmacokinetic data | |
| Duration of action | Unknown[1][2][3][4] |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
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| Chemical and physical data | |
| Formula | C13H21NO2S |
| Molar mass | 255.38 g·mol−1 |
| 3D model (JSmol) | |
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Ψ-2C-T-4, or psi-2C-T-4, also known as 4-isopropylthio-2,6-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and Ψ-PEA families.[1][4][2][3] It is a positional isomer of 2C-T-4 (4-isopropylthio-2,5-dimethoxyphenethylamine).[1][4][2][3]
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved), Ψ-2C-T-4 produced short-lasting threshold psychoactive effects at doses of 8 to 12 mg orally.[1][2][3] Higher doses were not assessed and its effective dose range has not been determined.[1][2][3] In a subsequent review, Shulgin stated that it was active at doses in the "10 to 20 mg range" but that more study was required to establish its dose range and effects.[4]
The chemical synthesis of Ψ-2C-T-4 has been described.[1]
The drug was first described in the scientific literature by Shulgin by 1991 and was further briefly described by him in 2003.[1][4][2] It is a controlled substance in Canada under phenethylamine blanket-ban language.[5]
See also
References
- ^ a b c d e f g h Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
- ^ a b c d e f g Shulgin A, Manning T, Daley P (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley: Transform Press. pp. 37–38. ISBN 978-0-9630096-3-0.
- ^ a b c d e f Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. p. 887. ISBN 978-3-03788-700-4. OCLC 858805226.
Das schwefelhaltige Ψ-2C-T-4 (55) wurde von Shulgin untersucht [1]. Es zeigte im Menschen bis 12mg lediglich Verdachtsmomente einer Wirkung und wurde nie in einer höheren Dosierung geprüft. Das Nicht-Pseudoanalogon 2C-T-4 (56) erwies sich im Bereich von 8—20mg als deutlich wirksam [1, 7].
- ^ a b c d e f Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
The 2,4,6-substituted positional isomer of 2-T-4, is, 4-isopropylthio-2,6-dimethoxyphenethylamine (Ψ-2C-T-4). In preliminary evaluations, it appears to be an active compound in the 10–20 milligrams range, but more studies are needed to firmly establish the dosage and the nature of the intoxication produced.
- ^ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.