IHCH-7086

IHCH-7086
Clinical data
Drug classNon-hallucinogenic serotonin 5-HT2A receptor agonist
Identifiers
  • (6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-8-[3-(2-methoxyphenyl)propyl]-3-methyl-1H-Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC24H31N3O
Molar mass377.532 g·mol−1
3D model (JSmol)
  • CN(CCN1[C@]2([H])[C@@]3([H])CN(CCCC4=CC=CC=C4OC)CC2)C5=C1C3=CC=C5
  • InChI=1S/C24H31N3O/c1-25-15-16-27-21-12-14-26(13-6-8-18-7-3-4-11-23(18)28-2)17-20(21)19-9-5-10-22(25)24(19)27/h3-5,7,9-11,20-21H,6,8,12-17H2,1-2H3/t20-,21-/m0/s1
  • Key:WFYFRJAKNJVZMP-SFTDATJTSA-N

IHCH-7086 is a non-hallucinogenic serotonin 5-HT2A receptor biased agonist of the pyridopyrroloquinoxaline family. It was derived via structural simplification of the serotonin 5-HT2A receptor antagonist and atypical antipsychotic lumateperone. The drug produces antidepressant-like effects but not psychedelic-like effects in rodents. Other related compounds include IHCH-7079, which is a non-hallucinogenic serotonin 5-HT2A receptor biased agonist similarly, and IHCH-7113, which produces the head-twitch response in rodents and hence would be expected to be hallucinogenic in humans.[1][2][3]

See also

References

  1. ^ US 6552017, Robichaud AJ, Lee T, Deng W, Mitchell IS, Yang MG, Haydar S, Chen W, Mc Clung CD, Calvello EJ, Zawrotny DM, "Substituted heterocycle fused gamma-carbolines.", issued 22 April 2003, assigned to Bristol Myers Squibb Pharma Co. 
  2. ^ US 9315504, Tomesch JC, Li P, Yao W, Zhang Q, Beard JD, Thompson AS, Cheng H, Wennogle LP, "Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof", issued 19 April 2016, assigned to Intra Cellular Therapies Inc. 
  3. ^ Cao D, Yu J, Wang H, Luo Z, Liu X, He L, et al. (January 2022). "Structure-based discovery of nonhallucinogenic psychedelic analogs". Science. 375 (6579): 403–411. Bibcode:2022Sci...375..403C. doi:10.1126/science.abl8615. PMID 35084960. S2CID 246360313.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.