βk-2C-I

βk-2C-I
Clinical data
Other names	bk-2C-I; β-Keto-2C-I; β-Keto-4-iodo-2,5-dimethoxyphenethylamine; 4-Iodo-2,5-dimethoxy-β-ketophenylethylamine; 4′-Iodo-2′,5′-dimethoxy-2-aminoacetophenone; 4-Iodo-2,5-dimethoxycathinone; 2,5MeO,4I-AcP
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None;
Identifiers
	IUPAC name 2-amino-1-(4-iodo-2,5-dimethoxyphenyl)ethanone;
PubChem CID	165361441;
Chemical and physical data
Formula	C10H12INO3
Molar mass	321.114 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=C(C=C1C(=O)CN)OC)I;
	InChI InChI=1S/C10H12INO3/c1-14-9-4-7(11)10(15-2)3-6(9)8(13)5-12/h3-4H,5,12H2,1-2H3; Key:SGQREGRMRKZYSF-UHFFFAOYSA-N;

βk-2C-I, or bk-2C-I, also known as β-keto-4-iodo-2,5-dimethoxyphenethylamine or as β-keto-2C-I, is a psychedelic drug of the phenethylamine and 2C families related to 2C-I.^[1]^[2] It is the β-keto derivative of 2C-I and is cathinone-like in chemical structure.^[1]^[2] The drug is closely related to βk-2C-B.^[1]^[2] It is said to have a longer duration than 2C-I and to not be as intense in its effects as βk-2C-B.^[1] Concerns have been expressed about the potential toxicity of the iodine in βk-2C-I.^[1] The interactions of βk-2C-I with monoamine oxidase have been studied.^[2] βk-2C-I was encountered as a novel designer drug online by at least 2016 and was first described in the scientific literature by 2018.^[1] βk-2C-I is a controlled substance in Canada under phenethylamine blanket-ban language.^[3]

References

^ ^a ^b ^c ^d ^e ^f Texter KB, Waymach R, Kavanagh PV, O'Brien JE, Talbot B, Brandt SD, et al. (January 2018). "Identification of pyrolysis products of the new psychoactive substance 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone hydrochloride (bk-2C-B) and its iodo analogue bk-2C-I" (PDF). Drug Testing and Analysis. 10 (1): 229–236. doi:10.1002/dta.2200. PMID 28371351. The general consensus is that bk-2C-B lasts about 10 h, noticeably longer than 2C–B. Negative effects of snorting include severe burning and purple mucus. Gastrointestinal effects including severe diarrhoea are also common.[13] The few user reports on the forums indicate that bk-2C-I also lasts longer, but does not produce as intense a high as bk-2C-I. Concerns were expressed about the toxicity of iodine.
^ ^a ^b ^c ^d Wagmann L, Brandt SD, Stratford A, Maurer HH, Meyer MR (February 2019). "Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases" (PDF). Drug Testing and Analysis. 11 (2): 318–324. doi:10.1002/dta.2494. PMID 30188017.
^ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.