HOT-17
| Clinical data | |
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| Other names | 4-sec-Butylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-sec-butylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-17; N-OH-2C-T-17 |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Pharmacokinetic data | |
| Metabolites | Possibly 2C-T-17[1][2] |
| Onset of action | 0.5–1.5 hours[1] Peak: 3 hours[1] |
| Duration of action | 12–18 hours[1] |
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| Chemical and physical data | |
| Formula | C14H23NO3S |
| Molar mass | 285.40 g·mol−1 |
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HOT-17, also known as 4-sec-butylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-17, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families.[1][3] It is the N-hydroxy derivative of 2C-T-17.[1][3] The drug is taken orally.[1]
Use and effects
In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-17's dose range as 70 to 120 mg orally and its duration as 12 to 18 hours.[1] The drug's onset is 30 minutes to 1.5 hours and peak effects occur after 3 hours.[1] HOT-17's properties are very similar to those of 2C-T-17, which has a dose of 60 to 100 mg orally, a duration of 10 to 15 hours, and an onset of 1 hour with a time to peak of 3 hours.[1][2] HOT-17 may act as a prodrug of 2C-T-17.[2]
The effects of HOT-17 have been reported to include "something going on upstairs", no sensory distortion, mild time distortion, feeling light and slightly floaty, walking feeling pleasant due to the lightness, and no body load, among others.[1] It was described as producing "plus-two" and "plus-three" experiences on the Shulgin Rating Scale.[1] The compound is said to have an "unbelievably grim taste—not bitter, but simply evil".[1]
Interactions
Chemistry
Synthesis
The chemical synthesis of HOT-17 has been described.[1]
Analogues
Analogues of HOT-17 include 2C-T-17, HOT-2 (N-hydroxy-2C-T-2), and HOT-7 (N-hydroxy-2C-T-7), among others.[1][3]
History
HOT-17 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1][3]
Society and culture
Legal status
Canada
HOT-17 is a controlled substance in Canada under phenethylamine blanket-ban language.[4]
See also
References
- ^ a b c d e f g h i j k l m n o p q Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. https://www.erowid.org/library/books_online/pihkal/pihkal089.shtml
- ^ a b c Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "#81 FLEA".
I first observed the intimate connection between an amine and a hydroxylamine with the discovery that N-hydroxy-MDA (MDOH) was equipotent and of virtually identical activity to the non-hydroxylated counterpart (MDA). And I have speculated in the recipe for MDOH about the possible biological interconversions of these kinds of compounds. And here, the simple addition of a hydroxyl group to the amine nitrogen atom of MDMA produces a new drug that is in most of its properties identical to MDMA. The concept has been extended to 2C-T-2, 2C-T-7, and 2C-T-17, where each of these three active compounds was structurally modified in exactly this way, by the addition of a hydroxyl group to the amine nitrogen atom. The results, HOT-2, HOT-7 and HOT-17 were themselves all active, and compared very closely with their non-hydroxylated prototypes.
- ^ a b c d Shulgin A, Manning T, Daley P (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley: Transform Press. ISBN 978-0-9630096-3-0.
- ^ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.