4-AcO-DET

4-AcO-DET
Clinical data
Other names4-Acetoxy-DET; 4-Acetoxy-N,N-diethyltryptamine; Ethacetin; Ethylacybin
Routes of
administration		Oral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class A
Pharmacokinetic data
Duration of action4–6 hours[1]
Identifiers
  • 3-(2-diethylaminoethyl)-1H-indol-4-yl acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H22N2O2
Molar mass274.364 g·mol−1
3D model (JSmol)
  • CC(OC1=CC=CC2=C1C(CCN(CC)CC)=CN2)=O
  • InChI=1S/C16H22N2O2/c1-4-18(5-2)10-9-13-11-17-14-7-6-8-15(16(13)14)20-12(3)19/h6-8,11,17H,4-5,9-10H2,1-3H3 Y
  • Key:ODVLAYUXIAMBFN-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

4-AcO-DET, also known as 4-acetoxy-N,N-diethyltryptamine as well as ethacetin or ethylacybin, is a psychedelic tryptamine.[1] It was first synthesized in 1958 by Albert Hofmann in the Sandoz lab.[2]

Use and effects

See also: 4-HO-DET § Use and effects

4-AcO-DET is orally active, and doses of 10 to 25 mg are common.[1] Effects last 4 to 6 hours.[1] The free base is also active when smoked in a dose range of 5 to 20 mg.[2] Smoking 4-AcO-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

See also: 4-HO-DET § Pharmacology

It is expected that 4-AcO-DET is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.[1]

Chemistry

Analogues

Analogues of 4-AcO-DET include diethyltryptamine (DET), 4-HO-DET (ethocin), ethocybin (4-PO-DET), 4-AcO-DMT (psilacetin), 4-AcO-DPT, 4-AcO-MET, and 4-AcO-MPT, among others.

Society and culture

Canada

4-AcO-DET is not an explicitly nor implicitly controlled substance in Canada as of 2025.[3]

Finland

Listed in the "government decree on psychoactive substances banned from the consumer market".[4]

Sweden

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-AcO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-acetoxi-N,N-dietyltryptamin (4-AcO-DET), making it illegal to sell or possess.[5]

United States

4-AcO-DET is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ^ a b c d e f Shulgin A, Shulgin A. "#16. 4-HO-DET". Tikhal: The Chemistry Continues. Retrieved 19 April 2007.
  2. ^ a b Erowid 4-Acetoxy-DET Vaults : Primer. Accessed on April 19, 2007.
  3. ^ "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  4. ^ "Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista".
  5. ^ Svensk författningssamling (13 October 2005). "Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor;" (PDF). Archived from the original (PDF) on 4 March 2016. Retrieved October 10, 2015.
  6. ^ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
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