5-MeO-DiBF
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| Other names | 5-MeO-DIBF; 5-MeO-DiPBF; 5-Methoxy-N,N-diisopropyl-3-(2-aminoethyl)benzofuran; 5-Methoxy-N,N-diisopropyl-benzofuranethylamine; 1-Oxa-5-MeO-DiPT |
| Routes of administration | Oral, insufflation[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Pharmacokinetic data | |
| Onset of action | 45 minutes[1] |
| Duration of action | 4–9 hours[1] |
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| Chemical and physical data | |
| Formula | C17H25NO2 |
| Molar mass | 275.392 g·mol−1 |
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5-MeO-DiBF, also known as 5-methoxy-N,N-diisopropyl-3-(2-aminoethyl)benzofuran or as 1-oxa-5-MeO-DiPT, is a psychedelic drug of the benzofuran family related to the psychedelic tryptamine 5-MeO-DiPT.[2][1][3] It is the analogue and bioisostere of 5-MeO-DiPT in which the indole nitrogen has been replaced with an oxygen atom, making it a benzofuran rather than tryptamine.[2] The drug has been sold online as a novel designer drug starting in 2015.[1][4]
Use and effects
The dose of 5-MeO-DiBF has been given as 10 to 40 mg orally, with a light dose being 10 mg, a common dose being 20 mg, and a strong dose being 40 mg.[1] Its onset is said to be 45 minutes and its duration is variably said to be 4 to 9 hours.[1] In addition to oral administration, the drug may also be insufflated.[1] The effects of 5-MeO-DiBF have been reported to include psychedelic head space, tactile sensations and tingling, and increased sexual desire, among others.[1]
Interactions
Pharmacology
Pharmacodynamics
Analogues of 5-MeO-DiBF have been found to interact with serotonin receptors including the serotonin 5-HT1A and 5-HT2 receptors.[5][6]
Chemistry
Analogues
Analogues of 5-MeO-DiBF include the benzofurans dimemebfe (5-MeO-BFE), MiPBF (1-oxa-MiPT), 3-APB (1-oxa-AMT), and mebfap (5-MeO-3-APB; 1-oxa-5-MeO-AMT) and the tryptamine 5-MeO-DiPT, among others.[3][2]
History
5-MeO-DiBF has been sold online as a designer drug and was first definitively identified in December 2015 by a forensic laboratory in Slovenia.[1][4]
Society and culture
Legal status
International
5-MeO-DiBF is not controlled under the United Nations 1971 Convention on Psychotropic Substances, so thus it has a legal grey area in many countries, but it's possible it could be illegal under so-called analogue acts if sold for human consumption.
Armenia
The drug is a controlled substance in Armenia as of 2022.[7]
Canada
5-MeO-DiBF is not a controlled substance in Canada as of 2025.[8]
United States
5-MeO-DiBF is not an explicitly controlled substance in the United States.[9] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
References
- ^ a b c d e f g h i j Trott DM (9 April 2019). "5-MeO-DiBF". The Drug Users Bible: Harm Reduction, Risk Mitigation, Personal Safety. MxZero Publishing. ISBN 978-0-9955936-8-8.
- ^ a b c Awuchi CG, Aja MP, Mitaki NB, Morya S, Amagwula IO, Echeta CK, et al. (2 February 2023). "New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions". Journal of Chemistry. 2023: 1–36. doi:10.1155/2023/5852315. ISSN 2090-9071.
- ^ a b Casale JF, Hays PA (2012). "The Characterization of 2-(5-Methoxy-1-benzofuran-3-yl)-N,N-dimethylethanamine (5-MeO-BFE) and Differentiation from its N-Ethyl Analog" (PDF). Microgram Journal. 9 (1): 39–45. Archived from the original (PDF) on 23 February 2015.
- ^ a b "Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA" (PDF). European Monitoring Center for Drugs and Drug Addiction.
- ^ Tomaszewski Z, Johnson MP, Huang X, Nichols DE (May 1992). "Benzofuran bioisosteres of hallucinogenic tryptamines". Journal of Medicinal Chemistry. 35 (11): 2061–2064. doi:10.1021/jm00089a017. PMID 1534585.
- ^ McKenna DJ, Repke DB, Lo L, Peroutka SJ (March 1990). "Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes". Neuropharmacology. 29 (3): 193–198. doi:10.1016/0028-3908(90)90001-8. PMID 2139186. S2CID 24188017.
- ^ "5-MeO-DIBF". АИПСИН (in Russian). Retrieved 1 January 2026.
- ^ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
- ^ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026