2C-T-8
| Clinical data | |
|---|---|
| Other names | 4-Cyclopropylmethylthio-2,5-dimethoxyphenethylamine; 2,5-Dimethoxy-4-cyclopropylmethylthiophenethylamine |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
| ATC code |
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| Pharmacokinetic data | |
| Onset of action | 0.75–1.5 hours[1] |
| Duration of action | 10–15 hours[1] |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
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| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C14H21NO2S |
| Molar mass | 267.39 g·mol−1 |
| 3D model (JSmol) | |
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2C-T-8, also known as 4-cyclopropylmethylthio-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.[1][2][3]
Use and effects
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2C-T-8's dose as 30 to 50 mg orally and its duration as 10 to 15 hours.[1][2][3] Its onset is 0.75 to 1.5 hours and is said to be smooth.[1]
The effects of 2C-T-8 have been reported to include good or excellent feelings, high energy, it being not too stimulating, thinking changes similar to those of 2C-T-2, feeling like one's head is split in two in the sense of being in two different universes at the same time, division of and discoordination of visual and spatial perceptions into two along a vertical axis, problems with boundaries such that the outside world seemed to be getting inside of one's head, feeling that parts of oneself separated uncontrollably or ran together into someone unfamiliar, feeling that the eyes were working independently of each other, opening of insights and understanding, feeling completely out of one's conscious body, feelings of awakening, introspection or internal journey, self-interaction, and personal development.[1]
Other effects included negative feelings, discomfort, self-doubt, paranoia, hypersensitivity to light, noise, and motion, sinus pain, nausea and vomiting, vertigo especially with closed eyes or laying down, sleep disturbances, and after-effects like a buzzing in the head, an uncertain balance, and feeling out of it for a few days to a week.[1] According to Shulgin, 2C-T-8 reports were mixed, with as many negatives as there were positives.[1] Some reports stated that it was "a good one" and that it produced "one of the most remarkable experiences I have ever had", whereas another report stated that it caused "not a crisis experience, but one of extreme and prolonged discomfort".[1] The drug is said to have an unpleasant smell and taste.[1]
Interactions
Chemistry
The full name of the chemical is 2,5-dimethoxy-4-cyclopropylmethylthiophenethylamine.[1] The compound is reported to have a bad taste and smell.[1]
Synthesis
The chemical synthesis of 2C-T-8 has been described.[1]
History
2C-T-8 was first described in the scientific literature by Alexander Shulgin and colleagues in 1991.[4] Subsequently, it was described in greater detail by Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) that same year.[1]
Society and culture
Legal status
Canada
As of October 31, 2016, 2C-T-8 is a controlled substance (Schedule III) in Canada.[5]
United States
2C-T-8 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-8 will probably be prosecuted under the Federal Analog Act because of its structural similarities to 2C-T-7. However, 2C-T-8, unlike many other phenethylamines has not been sold by internet retailers. In the wake of Operation Web Tryp in July 2004, the issue of possession and sales of 2C-T-8 and other similar chemicals will probably be resolved in the courtroom as will the fate of this rare but unique psychedelic.
See also
References
- ^ a b c d e f g h i j k l m n o Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. 2C-T-8 Entry
- ^ a b Jacob P, Shulgin AT (1994). "Structure-Activity Relationships of the Classic Hallucinogens and Their Analogs". In Lin GC, Glennon RA (eds.). Hallucinogens: An Update (PDF). National Institute on Drug Abuse Research Monograph Series. Vol. 146. National Institute on Drug Abuse. pp. 74–91. PMID 8742795. Archived from the original on 13 July 2025.
- ^ a b Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
- ^ Shulgin, Alexander T.; Shulgin, Ann; Jacob, Peyton (January 1991). "Letters to the Editor [Re: Stolaroff (1990) - Central Nervous System (CNS) Activity of Two New Psychoactive Compounds]". Journal of Psychoactive Drugs. 23 (1): 95–97 (95–96). doi:10.1080/02791072.1991.10472583. eISSN 2159-9777. ISSN 0279-1072. PMID 1941371. Archived from the original on 2025-07-13.
- ^ "Canada Gazette – Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)". 4 May 2016.