SB-649915

SB-649915
Clinical data
Other namesSB649915; SB-649,915
Drug classSerotonin reuptake inhibitor; Serotonin 5-HT1A receptor antagonist; Serotonin 5-HT1B receptor antagonist
ATC code
  • None
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 6-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]-4H-1,4-benzoxazin-3-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC26H29N3O3
Molar mass431.536 g·mol−1
3D model (JSmol)
  • CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC5=C(C=C4)OCC(=O)N5
  • InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30) N
  • Key:PJSUYRBCBFPCQW-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

SB-649915 is a serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects.[1] Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well.[1] This can be attributed to blockade of 5-HT1A and 5-HT1B autoreceptors which inhibit serotonin release.[1]

See also

References

  1. ^ a b c Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS (2007). "SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test". Neuropsychopharmacology. 32 (10): 2163–2172. doi:10.1038/sj.npp.1301341. PMID 17356576.
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