miR529 microRNA precursor family
| miR529 | |
|---|---|
| Identifiers | |
| Symbol | miR529 |
| Rfam | RF00908 |
| miRBase family | MIPF0000388 |
| Other data | |
| RNA type | microRNA |
| Domain | Viridiplantae |
| PDB structures | PDBe |
In molecular biology, miR529 is a plant microRNA that regulates gene expression through sequence-directed cleavage or translational repression of target mRNAs. miR529 is evolutionarily related to the conserved plant microRNA miR156, and both families regulate members of the SQUAMOSA promoter-binding protein-like (SPL) gene family.[1]
The miR529 and miR156 families share overlapping target sites in several SPL genes, resulting in combinatorial regulation of plant developmental processes. Phylogenetic analyses indicate that many miR529 targets derive from a subset of SPL genes that are also regulated by miR156, suggesting that the two microRNA families cooperate to control the evolution and functional diversification of SPL transcription factors.[2][3]
Evolutionary analyses suggest that miR529 arose early in land plant evolution but has been lost in several plant lineages, including many core eudicots such as Arabidopsis thaliana. In species lacking miR529, regulatory functions associated with this microRNA may be partially compensated by members of the miR156 family.[1]
Functional studies in crops such as rice have shown that miR156 and miR529 regulate plant architecture and reproductive development by controlling SPL gene expression. In rice, the two microRNAs exhibit distinct expression patterns, with miR156 acting mainly during vegetative development and miR529 functioning more prominently in reproductive tissues such as the panicle.[4]
See also
References
- ^ a b Ortiz-Morea EG, da Silva EM, Ferreira e Silva GF, Valente GT, Barrera Rojas CH, Vincentz M, Nogueira FT (2016). "Functional and evolutionary analyses of the miR156 and miR529 families in land plants". BMC Plant Biology. 16: 40. doi:10.1186/s12870-016-0716-5. PMC 4739381. PMID 26841873.
- ^ Ling LZ, Zhang SD (2012). "Exploring the evolutionary differences of SBP-box genes targeted by miR156 and miR529 in plants". Genetica. 140 (7–9): 317–324. doi:10.1007/s10709-012-9684-3. PMID 23054224.
- ^ Zhang SD, Ling LZ, Zhang QF, Xu JD, Cheng L (2015). "Evolutionary comparison of two combinatorial regulators of SBP-box genes, MiR156 and MiR529, in plants". PLOS ONE. 10 (4) e0124621. doi:10.1371/journal.pone.0124621. PMC 4409300. PMID 25909360.
- ^ Li Y, He Y, Qin T, Guo X, Xu K, Xu C, Yuan W (2023). "Functional conservation and divergence of miR156 and miR529 during rice development". The Crop Journal. 11 (3): 692–703. doi:10.1016/j.cj.2022.11.005.
External links