miR398 microRNA precursor family
| miR398 | |
|---|---|
| Identifiers | |
| Symbol | miR398 |
| Rfam | RF00695 |
| miRBase family | MIPF0000107 |
| Other data | |
| RNA type | microRNA |
| Domain | Viridiplantae |
| PDB structures | PDBe |
In molecular biology, miR398 is a conserved microRNA found in plants that regulates genes involved in copper homeostasis and oxidative stress responses.[1][2] Like other plant microRNAs, miR398 regulates gene expression primarily through sequence-directed cleavage of target mRNAs.
In Arabidopsis thaliana, miR398 targets transcripts encoding the copper/zinc superoxide dismutases CSD1 and CSD2, as well as the copper chaperone for superoxide dismutase (CCS).[1][3] Expression of miR398 is dynamically regulated by environmental conditions, including oxidative stress, sucrose signaling, and copper availability.[4][5]
Under copper deficiency, transcription factors such as SPL7 coordinate the induction of miR398 and related regulatory pathways to prioritize copper allocation to essential proteins.[2] Through this regulatory network, miR398 contributes to plant adaptation to oxidative and nutrient stress conditions.
See also
References
- ^ a b Sunkar R, Kapoor A, Zhu JK (August 2006). "Posttranscriptional induction of two Cu/Zn superoxide dismutase genes in Arabidopsis is mediated by downregulation of miR398 and important for oxidative stress tolerance". The Plant Cell. 18 (8): 2051–65. doi:10.1105/tpc.106.041673. PMC 1533975. PMID 16861386.
- ^ a b Yamasaki H, Abdel-Ghany SE, Cohu CM, Kobayashi Y, Shikanai T, Pilon M (June 2007). "Regulation of copper homeostasis by micro-RNA in Arabidopsis". The Journal of Biological Chemistry. 282 (22): 16369–78. doi:10.1074/jbc.M700138200. PMID 17405879.
- ^ Beauclair L, Yu A, Bouché N (May 2010). "microRNA-directed cleavage and translational repression of the copper chaperone for superoxide dismutase mRNA in Arabidopsis" (PDF). The Plant Journal. 62 (3): 454–62. doi:10.1111/j.1365-313X.2010.04162.x. PMID 20128885.
- ^ Dugas DV, Bartel B (July 2008). "Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases". Plant Molecular Biology. 67 (4): 403–17. doi:10.1007/s11103-008-9329-1. PMID 18392778. S2CID 22984450.
- ^ Abdel-Ghany SE, Pilon M (June 2008). "MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis". The Journal of Biological Chemistry. 283 (23): 15932–45. doi:10.1074/jbc.M801406200. PMC 3259626. PMID 18408011.
External links