miR395 microRNA precursor family
| miR395 microRNA precursor family | |
|---|---|
Predicted secondary structure and sequence conservation of miR395 | |
| Identifiers | |
| Symbol | miR395 |
| Rfam | RF00451 |
| miRBase | MI0001007 |
| miRBase family | MIPF0000016 |
| Other data | |
| RNA type | microRNA |
| Domain | Viridiplantae |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
In molecular biology, miR395 is a conserved plant microRNA that regulates genes involved in sulfur metabolism and transport. Like other plant microRNAs, miR395 controls gene expression by directing cleavage or translational repression of target mRNAs.[1]
miR395 was initially identified computationally in plants including Arabidopsis thaliana and Oryza sativa. Members of the miR395 family primarily target transcripts encoding ATP sulfurylase enzymes and sulfate transporters, key components of sulfate assimilation pathways.[1]
In Arabidopsis, expression of miR395 is strongly induced under sulfate-limiting conditions. The mature miRNA then regulates sulfate uptake and allocation by targeting ATP sulfurylase genes and the sulfate transporter SULTR2;1, helping coordinate sulfur homeostasis in plants.[2][3]
See also
References
- ^ a b Jones-Rhoades MW, Bartel DP (2004). "Computational identification of plant microRNAs and their targets, including a stress-induced miRNA". Molecular Cell. 14 (6): 787–799. doi:10.1016/j.molcel.2004.05.027. PMID 15200956.
- ^ Liang G, Yang F, Yu D (2010). "MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana". The Plant Journal. 62 (6): 1046–1057. doi:10.1111/j.1365-313X.2010.04216.x. PMID 20374528.
- ^ Liang G, Yu D (2010). "Reciprocal regulation among miR395, APS and SULTR2;1 in Arabidopsis thaliana". Plant Signaling & Behavior. 5 (10): 1257–1259. doi:10.4161/psb.5.10.12608. PMC 3115361. PMID 20935495.
External links