miR408 microRNA precursor family
| miR408 | |
|---|---|
| Identifiers | |
| Symbol | miR408 |
| Rfam | RF00690 |
| miRBase family | MIPF0000102 |
| Other data | |
| RNA type | microRNA |
| Domain | Viridiplantae |
| PDB structures | PDBe |
In molecular biology, miR408 is a conserved plant microRNA that regulates gene expression through sequence-directed cleavage or translational repression of target mRNAs. miR408 occurs broadly across flowering plants including Arabidopsis thaliana, Oryza sativa, and woody species such as poplar.[1]
miR408 primarily regulates genes encoding copper-binding proteins, including plantacyanin and members of the laccase family. Through these targets, miR408 contributes to the regulation of copper allocation and the broader "copper economy" network in plants that balances copper distribution among essential proteins.[2]
Expression of miR408 is controlled by environmental signals including copper availability and light. In Arabidopsis, the transcription factors HY5 and SPL7 coordinate transcriptional regulation of MIR408, linking copper homeostasis with light signaling and photosynthetic metabolism.[3]
Recent studies have revealed additional developmental and physiological roles for miR408. In Arabidopsis, the miR408–plantacyanin regulatory module influences reactive oxygen species homeostasis in guard cells, balancing plant growth with drought resistance.[4] miR408 has also been implicated in vascular development, where it promotes cambium formation and tracheary element differentiation during xylem development.[5]
In crop species, miR408 can influence growth and yield-related traits. For example, in rice the miR408 regulatory network participates in auxin signaling pathways controlling plant architecture.[6] Manipulation of miR408 expression has also been shown to affect lignification, biomass accumulation, and cell wall accessibility in poplar, demonstrating potential applications in bioenergy crop improvement.[7]
See also
References
- ^ Lu S, Yang C, Chiang VL (2011). "Conservation and diversity of microRNA-associated copper-regulatory networks in Populus trichocarpa". Journal of Integrative Plant Biology. 53 (11): 879–891. doi:10.1111/j.1744-7909.2011.01080.x. PMID 22013976.
- ^ Abdel-Ghany SE, Pilon M (2008). "MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis". The Journal of Biological Chemistry. 283 (23): 15932–15945. doi:10.1074/jbc.M801406200. PMC 3259626. PMID 18408011.
- ^ Zhang H, Zhao X, Li J, Cai H, Deng XW, Li L (2014). "MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper". The Plant Cell. 26 (12): 4933–4953. doi:10.1105/tpc.114.127340. PMC 4311192. PMID 25516599.
- ^ Yang Y, Xu L, Hao C, Wan M, Tao Y, Zhuang Y, Su Y, Li L (2024). "The microRNA408-plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells". The Plant Cell. 36 (10): 4338–4355. doi:10.1093/plcell/koae144. PMC 11448907. PMID 38723161.
- ^ Liu C, Li A, Guo Z, Chen N, Wang Y, Tang W, Wu Y, Liu J, Wang Z, Li L, He XQ (2024). "MicroRNA analysis reveals 2 modules that antagonistically regulate xylem tracheary element development in Arabidopsis". The Plant Cell. 37 (1) koaf011. doi:10.1093/plcell/koaf011. PMC 11760538. PMID 39792476.
- ^ Rong F, Lv Y, Deng P, Wu X, Zhang Y, Yue E, Shen Y, Muhammad S, Ni F, Bian H, Wei X, Zhou W, Hu P, Wu L (2024). "Switching action modes of miR408-5p mediates auxin signaling in rice". Nature Communications. 15 (1): 2525. doi:10.1038/s41467-024-46765-z. PMC 10958043. PMID 38514635.
- ^ Guo Y, Wang S, Yu K, Wang HL, Xu H, Song C, Zhao Y, Wen J, Fu C, Li Y, Wang S, Zhang X, Zhang Y, Cao Y, Shao F, Wang X, Deng X, Chen T, Zhao Q, Li L, Wang G, Grünhofer P, Schreiber L, Li Y, Song G, Dixon RA, Lin J (2023). "Manipulating microRNA miR408 enhances both biomass yield and saccharification efficiency in poplar". Nature Communications. 14 (1): 4285. doi:10.1038/s41467-023-39930-3. PMC 10354043. PMID 37463897.
External links