miR397 microRNA precursor family
| miR397 | |
|---|---|
| Identifiers | |
| Symbol | miR397 |
| Rfam | RF00704 |
| miRBase family | MIPF0000120 |
| Other data | |
| RNA type | microRNA |
| Domain | Viridiplantae |
| PDB structures | PDBe |
In molecular biology, miR397 is a conserved plant microRNA that regulates gene expression through sequence-directed cleavage or translational repression of target mRNAs. miR397 is widely conserved in flowering plants including Arabidopsis thaliana, Oryza sativa, and Populus trichocarpa.[1]
Members of the miR397 family primarily target transcripts encoding laccase enzymes, which are multicopper oxidases involved in processes such as lignin polymerization and plant cell wall formation.[1] Regulation of laccase expression by miR397 contributes to the control of lignin deposition and vascular development.
Expression of miR397 is influenced by copper availability. Under copper-limiting conditions, miR397 and related microRNAs are induced to down-regulate copper-containing proteins, allowing plants to conserve copper for essential processes such as photosynthetic electron transport.[2]
In rice (Oryza sativa), the miR397–LACCASE regulatory module has also been implicated in grain yield regulation. miR397-mediated control of laccase genes influences brassinosteroid signaling pathways, with downstream effects on growth and yield traits.[3]
See also
References
- ^ a b Lu S, Yang C, Chiang VL (2011). "Conservation and diversity of microRNA-associated copper-regulatory networks in Populus trichocarpa". Journal of Integrative Plant Biology. 53 (11): 879–891. doi:10.1111/j.1744-7909.2011.01080.x. PMID 22013976.
- ^ Abdel-Ghany SE, Pilon M (2008). "MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis". The Journal of Biological Chemistry. 283 (23): 15932–15945. doi:10.1074/jbc.M801406200. PMC 3259626. PMID 18408011.
- ^ Yu Y, He RR, Yang L, Feng YZ, Xue J, Liu Q, Zhou YF, Lei MQ, Zhang YC, Lian JP, Chen YQ (2024). "A transthyretin-like protein acts downstream of miR397 and LACCASE to regulate grain yield in rice". The Plant Cell. 36 (8): 2893–2907. doi:10.1093/plcell/koae147. PMC 11289628. PMID 38735686.
External links