miR390 microRNA precursor family

miR390
Identifiers
SymbolmiR390
RfamRF00689
miRBase familyMIPF0000101
Other data
RNA typemicroRNA
DomainEukaryota;
PDB structuresPDBe

The miR390 microRNA precursor family is a conserved plant microRNA family; mature miR390 is produced from MIR390 precursor transcripts. miR390 functions in the TAS3 trans-acting small interfering RNA pathway. miR390 is a conserved plant microRNA that directs the production of trans-acting siRNAs (ta-siRNAs) from TAS3 transcripts.[1][2] In flowering plants, miR390 is loaded into ARGONAUTE7 and functions in the conserved miR390–TAS3–AUXIN RESPONSE FACTOR regulatory pathway, which helps control plant development including lateral root growth and aspects of leaf patterning.[3][4][5]

Function

miR390 is best known for its role in initiating ta-siRNA biogenesis from TAS3 precursor transcripts.[1][2] In this pathway, miR390 binds to two target sites in TAS3, and this "two-hit" architecture is a defining feature of tasiRNA production from the TAS3 family.[2] The resulting phased tasiRNAs regulate several AUXIN RESPONSE FACTOR genes, especially ARF3 and ARF4, linking miR390 to auxin-related developmental patterning.[4][5]

Biogenesis and mechanism

Like other plant microRNAs, miR390 is produced from a stem-loop precursor. Genetic analysis in Arabidopsis thaliana identified mutants defective in processing of the MIR390a precursor, supporting its formation through the canonical plant microRNA biogenesis pathway.[6] Unlike many plant microRNAs, miR390 shows a specific association with ARGONAUTE7, an interaction required for normal TAS3 ta-siRNA formation.[3] This specialized AGO7–miR390 module is a distinctive feature of the pathway.[3]

Biological roles

The miR390–TAS3 pathway has been implicated in several aspects of plant development. In Arabidopsis, auxin regulates this pathway during lateral root development, and quantitative changes in miR390 and TAS3 tasiRNAs affect lateral root growth.[7][5] The pathway also contributes to developmental patterning in aerial tissues through regulation of ARF genes.[4] Related components of the pathway have also been studied in maize, where an ARGONAUTE7-like protein is required for normal leaf expansion.[8]

Evolution and conservation

miR390 is one of the conserved plant microRNAs and is associated with a broadly conserved TAS3 tasiRNA pathway across land plants.[9][10] This conservation has made miR390 an important model for studying the origin and diversification of small-RNA-guided regulatory networks in plants.[11]

See also

References

  1. ^ a b Allen E, Xie Z, Gustafson AM, Carrington JC (April 2005). "microRNA-directed phasing during trans-acting siRNA biogenesis in plants". Cell. 121 (2): 207–21. doi:10.1016/j.cell.2005.04.004. PMID 15851028. S2CID 18056486.
  2. ^ a b c Axtell MJ, Jan C, Rajagopalan R, Bartel DP (November 2006). "A two-hit trigger for siRNA biogenesis in plants". Cell. 127 (3): 565–77. doi:10.1016/j.cell.2006.09.032. PMID 17081978. S2CID 1413712.
  3. ^ a b c Montgomery TA, Howell MD, Cuperus JT, Li D, Hansen JE, Alexander AL, Chapman EJ, Fahlgren N, Allen E, Carrington JC (April 2008). "Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation". Cell. 133 (1): 128–41. doi:10.1016/j.cell.2008.02.033. PMID 18342362. S2CID 11174355.
  4. ^ a b c Fahlgren N, Montgomery TA, Howell MD, Allen E, Dvorak SK, Alexander AL, Carrington JC (May 2006). "Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA affects developmental timing and patterning in Arabidopsis". Current Biology. 16 (9): 939–44. doi:10.1016/j.cub.2006.03.065. PMID 16682356. S2CID 401176.
  5. ^ a b c Marin E, Jouannet V, Herz A, Lokerse AS, Weijers D, Vaucheret H, Nussaume L, Crespi MD, Maizel A (April 2010). "miR390, Arabidopsis TAS3 tasiRNAs, and their AUXIN RESPONSE FACTOR targets define an autoregulatory network quantitatively regulating lateral root growth". The Plant Cell. 22 (4): 1104–17. doi:10.1105/tpc.109.072553. PMC 2879756. PMID 20363771.
  6. ^ Cuperus JT, Montgomery TA, Fahlgren N, Burke RT, Townsend T, Sullivan CM, Carrington JC (January 2010). "Identification of MIR390a precursor processing-defective mutants in Arabidopsis by direct genome sequencing" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 107 (1): 466–71. Bibcode:2010PNAS..107..466C. doi:10.1073/pnas.0913203107. PMC 2806713. PMID 20018656.
  7. ^ Yoon EK, Yang JH, Lim J, Kim SH, Kim SK, Lee WS (March 2010). "Auxin regulation of the microRNA390-dependent transacting small interfering RNA pathway in Arabidopsis lateral root development". Nucleic Acids Research. 38 (4): 1382–91. doi:10.1093/nar/gkp1128. PMC 2831332. PMID 19969544.
  8. ^ Douglas RN, Wiley D, Sarkar A, Springer N, Timmermans MC, Scanlon MJ (May 2010). "ragged seedling2 Encodes an ARGONAUTE7-like protein required for mediolateral expansion, but not dorsiventrality, of maize leaves". The Plant Cell. 22 (5): 1441–51. doi:10.1105/tpc.109.071613. PMC 2899878. PMID 20453116.
  9. ^ Axtell MJ, Snyder JA, Bartel DP (June 2007). "Common functions for diverse small RNAs of land plants". The Plant Cell. 19 (6): 1750–69. doi:10.1105/tpc.107.051706. PMC 1955733. PMID 17601824.
  10. ^ Talmor-Neiman M, Stav R, Klipcan L, Buxdorf K, Baulcombe DC, Arazi T (November 2006). "Identification of trans-acting siRNAs in moss and an RNA-dependent RNA polymerase required for their biogenesis". The Plant Journal. 48 (4): 511–21. doi:10.1111/j.1365-313X.2006.02895.x. PMID 17076803.
  11. ^ Krasnikova MS, Milyutina IA, Bobrova VK, Ozerova LV, Troitsky AV, Solovyev AG, Morozov SY (2009). "Novel miR390-dependent transacting siRNA precursors in plants revealed by a PCR-based experimental approach and database analysis". Journal of Biomedicine & Biotechnology. 2009 952304. doi:10.1155/2009/952304. PMC 2762245. PMID 19859540.


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