Phescaline
| Clinical data | |
|---|---|
| Other names | PH; 4-Phenoxy-3,5-dimethoxyphenethylamine; 3,5-Dimethoxy-4-phenoxyphenethylamine |
| Routes of administration | Unknown |
| ATC code |
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| Identifiers | |
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| Chemical and physical data | |
| Formula | C16H19NO3 |
| Molar mass | 273.332 g·mol−1 |
| 3D model (JSmol) | |
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Phescaline (PH), also known as 4-phenoxy-3,5-dimethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to the psychedelic drug mescaline.[1] It is the derivative of mescaline in which the methoxy group at the 4 position has been replaced with a phenoxy group.[1]
According to Daniel Trachsel and colleagues in their book Phenethylamine: von der Struktur zur Funktion, phescaline is not known to have been synthesized, studied, or tested in humans.[1] However, analogues of phescaline like benzscaline (BZ) and 3C-BZ are known to be potent serotonin 5-HT2A receptor agonists and/or psychedelics, and phescaline may be active as a psychedelic similarly.[1][2][3] On the other hand, the longer-chain analogue phenescaline was found to have little activity in humans at tested doses.[1][3]
Phescaline was first described in the literature by Trachsel and colleagues in Phenethylamine: von der Struktur zur Funktion in 2013.[1]
See also
References
- ^ a b c d e f Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
- ^ Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Frontiers in Pharmacology. 12 794254. doi:10.3389/fphar.2021.794254. PMC 8865417. PMID 35222010.
- ^ a b Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.