Florence (drug)

Florence
Clinical data
Other namesFLORENCE; DOM-2ETO; 2-Ethoxy-5-methoxy-4-methylamphetamine; 2-Ethoxy-4-methyl-5-methoxyamphetamine
Routes of
administration		Unknown[1]
ATC code
  • None
Pharmacokinetic data
Duration of actionUnknown[1]
Identifiers
  • 1-(2-ethoxy-5-methoxy-4-methylphenyl)propan-2-amine
Chemical and physical data
FormulaC13H21NO2
Molar mass223.316 g·mol−1
3D model (JSmol)
  • CCOc1cc(C)c(cc1CC(N)C)OC
  • InChI=1S/C13H21NO2/c1-5-16-13-6-9(2)12(15-4)8-11(13)7-10(3)14/h6,8,10H,5,7,14H2,1-4H3
  • Key:JGTKJASRYQAIDY-UHFFFAOYSA-N

Florence, also known as 2-ethoxy-5-methoxy-4-methylamphetamine or as DOM-2ETO, is a chemical compound of the phenethylamine, amphetamine, and DOx families related to DOM.[1][2] It is the derivative of DOM in which the methoxy group at the 2 position has been replaced with an ethoxy group analogously to in the TWEETIO series.[1][2] According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved), Florence may have been synthesized but is not known to have been tested.[1][2] Along with its positional isomer Iris (DOM-5ETO), the compound is one of Shulgin's "ten classic ladies", a series of methylated DOM derivatives.[1][2] Florence was first described in the literature by at least 1970.[1][3] The drug is not an explicitly controlled substance in the United States, but may be considered scheduled as an isomer of DOET.[4][5] It is a controlled substance in Canada due to phenethylamine blanket-ban language.[6]

See also

References

  1. ^ a b c d e f g Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "And there are five positions (2,3,4,5 and 6) around the aromatic ring, each of which either carries a hydrogen atom or a methyl group that has a hydrogen atom. There is the 2-methoxy group which can become a 2-ethoxy group to produce a compound called FLORENCE. Her name is the English translation of the Italian Firenze, a city that, although having a female name, has always seemed thoroughly masculine to me. [...] and the other ethoxy homologue, FLORENCE, would be easily made based on the preparation of the phenethylamine analogue, 2CD-2ETO. Perhaps it has already been made somehow, somewhere, as I have noted that I have claimed its citrate salt as a new compound in a British patent."
  2. ^ a b c d Ger A, Ger D. "Triple Goddess of the Night". British Neuroscience Association Bulletin. 63: 28–30.
  3. ^ "phenethylamines and their pharmacologically-acceptable salts". Google Patents. 14 July 1969. Retrieved 26 November 2025.
  4. ^ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  5. ^ Drug Enforcement Administration (3 December 2007). "Definition of "Positional Isomer" as It Pertains to the Control of Schedule I Controlled Substances". Federal Register.
  6. ^ "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
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