SePP

SePP
Identifiers
  • 1-(2-phenyl-1-selenophen-2-ylethyl)piperidine
Chemical and physical data
FormulaC17H21NSe
Molar mass318.333 g·mol−1
3D model (JSmol)
  • C1=CC=CC=C1CC(N2CCCCC2)C3[Se]C=CC=3
  • InChI=InChI=1S/C17H21NSe/c1-3-8-15(9-4-1)14-16(17-10-7-13-19-17)18-11-5-2-6-12-18/h1,3-4,7-10,13,16H,2,5-6,11-12,14H2
  • Key:WBOODFQEMOGDKL-UHFFFAOYSA-N

SePP is a compound derived from the dissociative anesthetic diphenidine but containing an unusual selenophene ring, which shows both NMDA antagonist effects and with weaker activity as a norepinephrine–dopamine reuptake inhibitor, and has been researched as a potential treatment agent for Fragile X syndrome.[1]


See also

References

  1. ^ Wallach J, Cameron S, Dybek M, Stanley B, Orme C, Riad N, et al. (February 2026). "Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome". Journal of Medicinal Chemistry acs.jmedchem.5c02700. doi:10.1021/acs.jmedchem.5c02700. PMID 41666325.
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