Protoporphyrinogen IX dehydrogenase (menaquinone)
| Protoporphyrinogen IX dehydrogenase (menaquinone) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.5.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Protoporphyrinogen IX dehydrogenase (menaquinone) (EC 1.3.5.3, HemG) is an enzyme with systematic name protoporphyrinogen IX:menaquinone oxidoreductase.[1] This enzyme catalyses the following chemical reaction
The enzyme uses three equivalents of menaquinone per molecule of protoporphyrinogen IX to provide the oxidant. It enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments.[2][3]
References
- ^ Boynton TO, Daugherty LE, Dailey TA, Dailey HA (July 2009). "Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity". Biochemistry. 48 (29): 6705–11. doi:10.1021/bi900850y. PMC 2749469. PMID 19583219.
- ^ Enzyme 1.3.5.3 at KEGG Pathway Database.
- ^ Möbius, Kalle; Arias-Cartin, Rodrigo; Breckau, Daniela; Hännig, Anna-Lena; Riedmann, Katrin; Biedendieck, Rebekka; Schröder, Susanne; Becher, Dörte; Magalon, Axel; Moser, Jürgen; Jahn, Martina; Jahn, Dieter (2010). "Heme biosynthesis is coupled to electron transport chains for energy generation". Proceedings of the National Academy of Sciences. 107 (23): 10436–10441. doi:10.1073/pnas.1000956107. PMC 2890856. PMID 20484676.
External links
- Protoporphyrinogen+IX+dehydrogenase+(menaquinone) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)