Pyrroloquinoline-quinone synthase
| Pyrroloquinoline-quinone synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.3.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, pyrroloquinoline-quinone synthase (EC 1.3.3.11) is an enzyme that catalyzes the chemical reaction
The substrates of this enzyme are 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylic acid (AHQQ)[1] and three equivalents of oxygen. Its products are the redox cofactor pyrroloquinoline quinone, two equivalents of hydrogen peroxide, and one of water.[2][3] The details of the stereochemistry of the starting material are not known,[4][5] although the structure of the enzyme from Klebsiella pneumoniae has been established.[6]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinol ine-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing). This enzyme is also called PqqC.
References
- ^ Zhu, W; Klinman, JP (December 2020). "Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone". Current Opinion in Chemical Biology. 59: 93–103. doi:10.1016/j.cbpa.2020.05.001. PMC 7736144. PMID 32731194.
- ^ Enzyme 1.3.3.11 at KEGG Pathway Database.
- ^ Toyama H, Chistoserdova L, Lidstrom ME (1997). "Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate". Microbiology. 143 (2): 595–602. doi:10.1099/00221287-143-2-595. PMID 9043136.
- ^ Magnusson OT, Toyama H, Saeki M, Schwarzenbacher R, Klinman JP (2004). "The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis". J. Am. Chem. Soc. 126 (17): 5342–3. Bibcode:2004JAChS.126.5342M. doi:10.1021/ja0493852. PMID 15113189.
- ^ Klinman JP, Schwarzenbacher R (2004). "Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 7913–8. Bibcode:2004PNAS..101.7913M. doi:10.1073/pnas.0402640101. PMC 419531. PMID 15148379.
- ^ RC; Stenner-Liewen, F; Liewen, H; Reed, JC; Liddington, RC (2004). "Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution". Proteins. 56 (2): 401–3. doi:10.1002/prot.20085. PMID 15211525. S2CID 11735291.