Phthalate 4,5-cis-dihydrodiol dehydrogenase
| phthalate 4,5-cis-dihydrodiol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.64 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, phthalate 4,5-cis-dihydrodiol dehydrogenase (EC 1.3.1.64) is an enzyme that catalyzes the chemical reaction
4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid
+ NAD+
H+
H+
4,5-dihydroxyphthalic acid
+ NADH
The two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 4,5-dihydroxyphthalic acid, reduced NADH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.
References
- ^ Enzyme 1.3.1.64 at KEGG Pathway Database.
- ^ Batie CJ, LaHaie E, Ballou DP (1987). "Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia". J. Biol. Chem. 262 (4): 1510–8. doi:10.1016/S0021-9258(19)75664-6. PMID 3805038.