Nodular sclerosing Hodgkin lymphoma

Nodular sclerosing Hodgkin lymphoma
Other namesNodular sclerosis
The distinct nodules on the cut surface of this lymph node strongly suggest the diagnosis of nodular sclerosis.
SpecialtyOncology 

Nodular sclerosing Hodgkin lymphoma ("NSHL") or Nodular sclerosis is a form of Hodgkin lymphoma[1] that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands.[2]

The British National Lymphoma Investigation further categorized NSHL based upon Reed–Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment.[3]

References

  1. ^ Falchi L, Capello D, Palumbo B, et al. (November 2007). "A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy". Eur. J. Haematol. 79 (5): 455–61. doi:10.1111/j.1600-0609.2007.00952.x. PMC 2121125. PMID 17908180.
  2. ^ "Lacunar Cells in Classical Hodgkin Lymphoma". imagebank.hematology.org. Retrieved 2026-01-07.
  3. ^ Mauch, Peter; James Armitage; Volker Diehl; Richard Hoppe; Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. p. 107. ISBN 978-0-7817-1502-7.
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