Greek National Road 38

National Road 38 (Greek: Εθνική Οδός 38, abbreviated as EO38) is a single carriageway road in western and central Greece. It connects Thermo with Lamia, via Agrinio and Karpenisi. It passes through the regional units Aetolia-Acarnania, Evrytania and Phthiotis. One section coincides with the European route E952. The E962 goes between Agrinio and Lamia.^[1]

The western end of the National Road is in the small town Thermo, in Aetolia-Acarnania. It first runs west along the northern shore of Lake Trichonida. It turns north at Agrinio, and continues through the sparsely populated mountains of northeastern Aetolia-Acarnania. The highway crosses the Kremasta reservoir by the Episkopi bridge. It continues east through the mountainous Agrafa area, part of the Pindus mountains. It passes through Karpenisi, the capital town of Evrytania. East of Karpenisi, it passes through a tunnel under the Tymfristos mountain and enters the Spercheios valley. It follows the river Spercheios downstream, through Makrakomi and Leianokladi, and ends in Lamia. The National Road 38 passes through the following places:

• Thermo
• Paravola
• Agrinio
• Agios Vlasios
• Episkopi
• Fragkista
• Kalesmeno
• Karpenisi
• Tymfristos
• Agios Georgios Tymfristou
• Makrakomi
• Leianokladi
• Lamia

Ministerial Decision G25871 of 9 July 1963 created the EO38 from the old EO21 and EO78, both of which existed by royal decree from 1955 until 1963: the old EO21 followed the same route as the current EO38 between Lamia and Agrinio, while the old EO78 followed the same route between Agrinio and Thermo.^[2][3]

38°54′27″N 21°50′07″E / 38.9075°N 21.8354°E / 38.9075; 21.8354