Geranylgeranyl diphosphate reductase
| Geranylgeranyl diphosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Geranylgeranyl diphosphate reductase (EC 1.3.1.83, geranylgeranyl reductase, CHL P) is an enzyme with systematic name geranylgeranyl-diphosphate:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
The substrate of this enzyme is geranylgeranyl pyrophosphate, which reacts with three equivalents of reduced nicotinamide adenine dinucleotide phosphate (NADPH), and three protons. The product is phytyl diphosphate and oxidised NADP+.[3] It can also act on geranylgeranyl-chlorophyll a.[4]
References
- ^ Soll J, Schultz G, Rüdiger W, Benz J (April 1983). "Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts". Plant Physiology. 71 (4): 849–54. doi:10.1104/pp.71.4.849. PMC 1066133. PMID 16662918.
- ^ Keller Y, Bouvier F, d'Harlingue A, Camara B (January 1998). "Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase". European Journal of Biochemistry. 251 (1–2): 413–7. doi:10.1046/j.1432-1327.1998.2510413.x. PMID 9492312.
- ^ Enzyme 1.3.1.83 at KEGG Pathway Database.
- ^ Tanaka R, Oster U, Kruse E, Rudiger W, Grimm B (July 1999). "Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase". Plant Physiology. 120 (3): 695–704. doi:10.1104/pp.120.3.695. PMC 59307. PMID 10398704.
External links
- Geranylgeranyl+diphosphate+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)