GSK-958108

GSK-958108
Clinical data
Other namesGSK958108
Drug classSerotonin 5-HT1A receptor antagonist
ATC code
  • None
Identifiers
  • 7-methyl-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4,5-dihydroimidazo[1,5-a]quinoline-3-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC29H32N6O
Molar mass480.616 g·mol−1
3D model (JSmol)
  • CC1=C(C2=C(C=C1)N3C=NC(=C3CC2)C(=O)N)CCN4CCN(CC4)C5=CC=CC6=C5C=CC(=N6)C
  • InChI=1S/C29H32N6O/c1-19-6-10-26-22(9-11-27-28(29(30)36)31-18-35(26)27)21(19)12-13-33-14-16-34(17-15-33)25-5-3-4-24-23(25)8-7-20(2)32-24/h3-8,10,18H,9,11-17H2,1-2H3,(H2,30,36)
  • Key:RKWZRKZRPIUILS-UHFFFAOYSA-N

GSK-958108 is a serotonergic drug derived from the phenylpiperazine family which acts as a potent and selective 5-HT1A receptor antagonist, and has been researched as a potential treatment for sexual dysfunction.[1][2]

See also

References

  1. ^ WO 2009/090202, Anderton CL, Woollam GR, "Monomaleate monohydrate salt of a 5ht1a receptor antagonist.", published 23 July 2009, assigned to Glaxo Group Ltd. 
  2. ^ Fiorino F, Severino B, Magli E, Ciano A, Caliendo G, Santagada V, et al. (June 2014). "5-HT(1A) receptor: an old target as a new attractive tool in drug discovery from central nervous system to cancer". Journal of Medicinal Chemistry. 57 (11): 4407–4426. doi:10.1021/jm400533t. PMID 24295064.
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