Delta14-sterol reductase
| delta14-sterol reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.70 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, Delta14-sterol reductase (EC 1.3.1.70) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 14-demethyllanosterol and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol, reduced NADPH, and a proton.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ Delta14-oxidoreductase. This enzyme participates in biosynthesis of steroids.
References
- ^ Enzyme 1.3.1.70 at KEGG Pathway Database.
- ^ Bottema CK, Parks LW (1978). "Delta14-sterol reductase in Saccharomyces cerevisiae". Biochim. Biophys. Acta. 531 (3): 301–7. doi:10.1016/0005-2760(78)90212-6. PMID 32908.
- ^ Paik YK, Trzaskos JM, Shafiee A, Gaylor JL (1984). "Microsomal enzymes of cholesterol biosynthesis from lanosterol Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase". J. Biol. Chem. 259 (21): 13413–23. doi:10.1016/S0021-9258(18)90710-6. PMID 6444198.