Diclazafone desglycyl

Diclazafone desglycyl
Identifiers
  • 2-amino-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC15H12Cl2N2O2
Molar mass323.17 g·mol−1
3D model (JSmol)
  • C1=CC=C(C(=C1)C(=O)C2=C(C=CC(=C2)Cl)NC(=O)CN)Cl
  • InChI=1S/C15H12Cl2N2O2/c16-9-5-6-13(19-14(20)8-18)11(7-9)15(21)10-3-1-2-4-12(10)17/h1-7H,8,18H2,(H,19,20)
  • Key:YGKSPOBIXHTPMV-UHFFFAOYSA-N

Diclazafone desglycyl is a chemical compound that can act as both a prodrug and a synthetic precursor for the benzodiazepine derivative delorazepam, the N-desmethyl derivative of the designer benzodiazepine diclazepam. It is inactive in vitro but has similar effects to delorazepam in vivo due to metabolic conversion to the active benzodiazepine form.[1] It has been detected as a designer drug, first being identified in Denmark in September 2024.[2]

See also

References

  1. ^ Fryer RI, Leimgruber W, Trybulski EJ (September 1982). "Quinazolines and 1,4-benzodiazepines. 90. Structure-activity relationship between substituted 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamides and 1,4-benzodiazepinones". Journal of Medicinal Chemistry. 25 (9): 1050–1055. doi:10.1021/jm00351a009. PMID 6127410.
  2. ^ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.