Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
Identifiers
EC no.1.3.1.29
CAS no.53986-49-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase (EC 1.3.1.29) is an enzyme that catalyzes the chemical reaction

cis 1,2 dihydroxy-1,2-dihydronaphthalene
+ NAD+
 
 
 
H+
 
H+
 
1,2-naphthalenediol
+ NADH
 

The two substrates of this enzyme are (1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthalene and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 1,2-naphthalenediol, reduced NADH, and a proton.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase. Other names in common use include (+)-cis-naphthalene dihydrodiol dehydrogenase, naphthalene dihydrodiol dehydrogenase, and cis-dihydrodiol naphthalene dehydrogenase. This enzyme participates in 1- and 2-methylnaphthalene degradation and naphthalene and anthracene degradation.[1]

References

  1. ^ a b Enzyme 1.3.1.29 at KEGG Pathway Database.
  2. ^ Patel TR, Gibson DT (1974). "Purification and properties of (plus)-cis-naphthalene dihydrodiol dehydrogenase of Pseudomonas putida". J. Bacteriol. 119 (3): 879–88. doi:10.1128/jb.119.3.879-888.1974. PMC 245694. PMID 4369091.