Alpha-santonin 1,2-reductase

alpha-santonin 1,2-reductase
Identifiers
EC no.1.3.1.47
CAS no.111070-23-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, alpha-santonin 1,2-reductase (EC 1.3.1.47) is an enzyme that catalyzes the chemical reaction

 
 
H+
 
H+
 
 
1,2-dihydrosantonin
+ NAD+
 

The three substrates of this enzyme are santonin, reduced nicotinamide adenine dinucleotide (NADH), and a proton. Its products are 1,2-dihydrosantonin and oxidised NAD+. The enzyme can also use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase.

References

  1. ^ Enzyme 1.3.1.47 at KEGG Pathway Database.
  2. ^ Naik U, Mavuinkurve S (1987). "alpha-Santonin 1,2-reductase and its role in the formation of dihydrosantonin and lumisantonin by Pseudomonas cichorii S". Can. J. Microbiol. 33 (8): 658–62. doi:10.1139/m87-115. PMID 3690421.