6-hydroxynicotinate reductase
| 6-hydroxynicotinate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.7.1 | ||||||||
| CAS no. | 9030-84-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, 6-hydroxynicotinate reductase (EC 1.3.7.1) is an enzyme that catalyzes the chemical reaction
6-hydroxynicotinic acid
+ reduced ferredoxin
1,4,5,6-tetrahydro-6-oxonicotinic acid
+ oxidised ferredoxin
The two substrates of this enzyme are 6-hydroxynicotinic acid and reduced ferredoxin. Its products are 1,4,5,6-tetrahydro-6-oxonicotinic acid and oxidized ferredoxin.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase. Other names in common use include 6-oxotetrahydronicotinate dehydrogenase, 6-hydroxynicotinic reductase, HNA reductase, and 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase.
References
- ^ Enzyme 1.3.7.1 at KEGG Pathway Database.
- ^ Holcenberg JS, Tsai L (1969). "Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid". J. Biol. Chem. 244 (5): 1204–11. doi:10.1016/S0021-9258(18)91830-2. PMID 5767303.