The 2021 Indiana State Sycamores football team represented Indiana State University as a member of the Missouri Valley Football Conference (MVFC) for the 2021 NCAA Division I FCS football season. Led by fourth-year head coach Curt Mallory, the Sycamores compiled an overall record of 5–6 with a mark of 3–5 in conference play, tying for seventh place in the MVFC. Indiana State played home games at Memorial Stadium in Terre Haute, Indiana.
Schedule
| Date | Time | Opponent | Site | TV | Result | Attendance |
|---|
| August 28 | 6:00 p.m. | Eastern Illinois* | | ESPN+ | W 26–21 | 5,540 |
| September 11 | 12:00 p.m. | at Northwestern* | | BTN | L 6–24 | 26,181 |
| September 18 | 7:00 p.m. | at Eastern Kentucky* | | ESPN+ | W 23–21 | 4,550 |
| September 25 | 1:00 p.m. | No. 2 South Dakota State | - Memorial Stadium
- Terre Haute, IN
| | L 0–44 | 6,652 |
| October 2 | 3:00 p.m. | at South Dakota | | | L 10–38 | 6,267 |
| October 9 | 1:00 p.m. | Western Illinois | - Memorial Stadium
- Terre Haute, IN
| ESPN+ | W 37–27 | 3,943 |
| October 16 | 3:00 p.m. | at No. 20 Missouri State | | ESPN+ | L 7–37 | 14,336 |
| October 23 | 1:00 p.m. | Youngstown State | - Memorial Stadium
- Terre Haute, IN
| ESPN+ | W 28–17 | 5,479 |
| October 30 | 3:30 p.m. | at No. 2 North Dakota State | | ESPN+ | L 2–44 | 14,383 |
| November 13 | 1:00 p.m. | No. 15 Southern Illinois | - Memorial Stadium
- Terre Haute, IN
| ESPN3 | L 21-47 | 3,265 |
| November 20 | 1:00 p.m. | at Illinois State | | Marquee | W 15-10 | 2,890 |
- *Non-conference game
- Homecoming
- Rankings from STATS Poll released prior to the game
- All times are in Eastern time
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[1][2][3]
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