The 2021 Illinois State Redbirds football team represented Illinois State University as a member of the Missouri Valley Football Conference (MVFC) during the 2021 NCAA Division I FCS football season. Led by 13th-year head coach Brock Spack, the Redbirds compiled an overall record of 4–7 with a mark of 2–6 in conference play, placing in a three-way tie for ninth in the MVFC. Illinois State played home games at Hancock Stadium in Normal, Illinois.
Schedule
| Date | Time | Opponent | Site | TV | Result | Attendance |
|---|
| September 4 | 6:30 p.m. | Butler* | | Marquee / ESPN3 | W 49–7 | 8,148 |
| September 11 | 4:00 p.m. | at Western Michigan* | | ESPN3 | L 0–28 | 18,122 |
| September 18 | 6:00 p.m. | at Eastern Illinois* | | ESPN+ | W 31–24 | 6,424 |
| September 25 | 2:00 pm | at No. 7 Southern Illinois | | ESPN+ | L 17–35 | 8,618 |
| October 2 | 1:00 p.m. | No. 16 Missouri State | - Hancock Stadium
- Normal, IL
| Marquee / ESPN+ | L 20–41 | 0 |
| October 16 | 2:00 p.m. | No. 3 North Dakota State | - Hancock Stadium
- Normal, IL
| Marquee / ESPN+ | L 0–20 | 12,416 |
| October 23 | 1:00 p.m. | at No. 15 South Dakota | | ESPN+ | W 20–14 | 5,415 |
| October 30 | 3:00 p.m. | at Western Illinois | | ESPN3 | L 31–38 | 2,118 |
| November 6 | 12:00 p.m. | No. 13 Northern Iowa | - Hancock Stadium
- Normal, IL
| Marquee / ESPN+ | W 17–10 OT | 6,000 |
| November 13 | 2:00 p.m. | at North Dakota | | ESPN+ | L 7–14 | 6,141 |
| November 20 | 12:00 p.m. | Indiana State | - Hancock Stadium
- Normal, IL
| Marquee / ESPN+ | L 10-15 | 2,890 |
- *Non-conference game
- Homecoming
- Rankings from STATS Poll released prior to the game
- All times are in Central time
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