Vesugen

Vesugen
Identifiers
  • (2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2,6-diaminohexanoyl]amino]butanoyl]amino]butanedioic acid
CAS Number
PubChem CID
ChemSpider
ChEBI
Chemical and physical data
FormulaC15H26N4O8
Molar mass390.393 g·mol−1
3D model (JSmol)
  • C(CCN)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)N
  • InChI=1S/C15H26N4O8/c16-6-2-1-3-8(17)13(24)18-9(4-5-11(20)21)14(25)19-10(15(26)27)7-12(22)23/h8-10H,1-7,16-17H2,(H,18,24)(H,19,25)(H,20,21)(H,22,23)(H,26,27)/t8-,9-,10-/m0/s1
  • Key:LLSUNJYOSCOOEB-GUBZILKMSA-N

Vesugen (T-38) is a tripeptide with the sequence KED or Lys-Glu-Asp. It is one of a number of small peptides developed in Russia in the late 1990s and early 2000s[1] which are purported to have anti-aging effects.[2][3] Vesugen is claimed to stimulate proliferation and protein synthesis in fibroblast cells in the skin and to improve the appearance of skin,[4][5] as well as promoting neurotropic effects in brain tissue,[6][7][8] giving it a similar pharmacological profile to those claimed for the matrikine peptides produced by Western cosmetic skincare companies.


See also

References

  1. ^ RU 2295970, Khavinson VK, Grigor'ev EI, Malinin VV, Ryzhak GA, "Peptide enhancing resistance of capillaries, pharmaceutical composition based on thereof and method for its use", issued 27 March 2007, assigned to SIA Peptaids 
  2. ^ Khavinson VK, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM (May 2012). "Peptides tissue-specifically stimulate cell differentiation during their aging". Bulletin of Experimental Biology and Medicine. 153 (1): 148–151. doi:10.1007/s10517-012-1664-1. PMID 22808515.
  3. ^ Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B (June 2020). "Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides". Molecular Biology Reports. 47 (6): 4323–4329. doi:10.1007/s11033-020-05506-3. PMID 32399807.
  4. ^ Voicekhovskaya MA, Chalisova NI, Kontsevaya EA, Ryzhak GA (January 2012). "Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats". Bulletin of Experimental Biology and Medicine. 152 (3): 357–359. doi:10.1007/s10517-012-1527-9. PMID 22803085.
  5. ^ Lin'kova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, et al. (May 2016). "Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro". Bulletin of Experimental Biology and Medicine. 161 (1): 175–178. doi:10.1007/s10517-016-3370-x. PMID 27259496.
  6. ^ Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N, et al. (2019). "Effect of short peptides on neuronal differentiation of stem cells". International Journal of Immunopathology and Pharmacology. 33 2058738419828613. doi:10.1177/2058738419828613. PMC 6376556. PMID 30791821.
  7. ^ Khavinson VK, Lin'kova NS, Umnov RS (May 2021). "Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease". Bulletin of Experimental Biology and Medicine. 171 (2): 190–193. doi:10.1007/s10517-021-05192-6. PMID 34173097.
  8. ^ Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D, et al. (October 2024). "Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes". International Journal of Molecular Sciences. 25 (21) 11363. doi:10.3390/ijms252111363. PMC 11546785. PMID 39518916.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.