Trimethyllead chloride
| Names | |
|---|---|
| IUPAC name
Chloro(trimethyl)plumbane[1]
| |
| Other names | |
| Identifiers | |
3D model (JSmol)
|
|
| ChemSpider | |
| ECHA InfoCard | 100.014.716 |
| EC Number |
|
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| (CH3)3PbCl | |
| Molar mass | 287.8 g·mol−1 |
| Appearance | Colorless liquid[2] |
| Limited[2] | |
| Solubility | Highly soluble in organic solvents[2] |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
|
Highly toxic |
| GHS labelling: | |
| Danger | |
| Related compounds | |
Related compounds
|
|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
| |
Trimethyllead chloride is an organolead compount with formula (CH3)3PbCl. It is a highly toxic colorless liquid.
Synthesis
Trimethyllead chloride can be synthesized by reacting tetramethyllead with hydrogen chloride.[3]
- Pb(CH3)4 + HCl → (CH3)3PbCl + CH4
Uses
Trimethyllead chloride is primarily used in organic synthesis and as a reagent in various chemical reactions, particularly in the preparation of organolead compounds.[2]
Biochemistry
Trimethyllead chloride inhibits δ‐aminolevulinic acid dehydratase (ALAD) in vitro, although to a lesser extent than triethyllead chloride.[4]
Reactions
Trimethyllead chloride reacts with hexamethyldilead to yield tetramethyllead and lead(II) chloride.[5]
Hazards
As typical of organolead compounds, trimethyllead chloride is a poison. It is highly toxic to the environment, with long-lasting effects.[2]
References
- ^ a b c d e f "Chlorotrimethylplumbane". pubchem.ncbi.nlm.nih.gov. Retrieved 27 February 2026.
- ^ a b c d e "CAS 1520-78-1: Trimethyllead chloride | CymitQuimica". cymitquimica.com. Retrieved 27 February 2026.
- ^ Blais, J S; Marshall, W D (27 January 1987). "Synthesis of 14 C-radiolabelled trimethyllead chloride". Applied Organometallic Chemistry. 1 (3): 251–260. doi:10.1002/aoc.590010307. Retrieved 27 February 2026 – via CrossRef.
- ^ Bondy, Stephen C. (27 January 1986). "Effect of triethyl lead chloride on δ-aminolevulinic acid dehydratase". Journal of Toxicology and Environmental Health. 18 (4): 639–649. doi:10.1080/15287398609530900. PMID 3735462. Retrieved 27 February 2026 – via CrossRef.
- ^ P. Arnold, Dennis; R. Wells, Peter (18 May 1976). "Hexamethyldilead: II. Reactions with trimethyllead and trimethyltin chlorides". Journal of Organometallic Chemistry. 111 (3): 285–296. doi:10.1016/S0022-328X(00)98138-5. Retrieved 27 February 2026 – via ScienceDirect.