Salutaridinol 7-O-acetyltransferase
| salutaridinol 7-O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.150 | ||||||||
| CAS no. | 156859-13-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, salutaridinol 7-O-acetyltransferase (EC 2.3.1.150) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are the alkaloid salutaridinol and acetyl-CoA. Its products are 7-O-acetylsalutaridinol and coenzyme-A (CoA).[1][2][3]
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:salutaridinol 7-O-acetyltransferase. This enzyme participates in alkaloid biosynthesis leading to thebaine and morphine.[3]
References
- ^ Enzyme 2.3.1.150 at KEGG Pathway Database.
- ^ Lenz R, Zenk MH (1995). "Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis". J. Biol. Chem. 270 (52): 31091–6. doi:10.1074/jbc.270.52.31091. PMID 8537369.
- ^ a b Tian Y, Kong L, Li Q, Wang Y, Wang Y, An Z, Ma Y, Tian L, Duan B, Sun W, Gao R, Chen S, Xu Z (November 2024). "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids". Natural Product Reports. 41 (11): 1787–1810. doi:10.1039/d4np00029c. PMID 39360417.