SZC-6

SZC-6
Clinical data
Drug class	Sirtuin-3 (SIRT3) activator
Identifiers
	IUPAC name 3-(2-bromo-4-hydroxyphenyl)-7-hydroxychromen-2-one;
CAS Number	2010938-41-5;
PubChem CID	141475102;
ChemSpider	129973363;
Chemical and physical data
Formula	C15H9BrO4
Molar mass	333.137 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC2=C(C=C1O)OC(=O)C(=C2)C3=C(C=C(C=C3)O)Br;
	InChI InChI=1S/C15H9BrO4/c16-13-6-9(17)3-4-11(13)12-5-8-1-2-10(18)7-14(8)20-15(12)19/h1-7,17-18H; Key:FKXHOWSOYGZBRG-UHFFFAOYSA-N;

SZC-6 is a drug from the coumarin family which acts as a sirtuin-3 (SIRT3) activator.^[1] It has been used in animal studies to study the potential role of SIRT3 activators in the treatment of complications arising from diabetes.^[2]^[3]

References

^ Li ZY, Lu GQ, Lu J, Wang PX, Zhang XL, Zou Y, et al. (March 2023). "SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice". Acta Pharmacologica Sinica. 44 (3): 546–560. doi:10.1038/s41401-022-00966-8. PMC 9958013. PMID 36042291.
^ Xuan A, Liu M, Zhang L, Lu G, Liu H, Zheng L, et al. (July 2025). "SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating the M1/M2 Macrophage Ratio and Inhibiting the MyD88/NF-χB Pathway". Pharmaceuticals. 18 (8): 1143. doi:10.3390/ph18081143. PMC 12389266. PMID 40872534.
^ Liu M, Xuan A, Zheng L, Li D, Chen C, Liu H, et al. (December 2025). "Novel coumarin derivative SZC-6 as an allosteric activator of SIRT3 alleviates diabetic kidney disease via the SIRT3-Foxo3a signaling axis". Free Radical Biology & Medicine. 240: 29–45. doi:10.1016/j.freeradbiomed.2025.08.019. PMID 40803419.

[1] Li ZY, Lu GQ, Lu J, Wang PX, Zhang XL, Zou Y, et al. (March 2023). "SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice". Acta Pharmacologica Sinica. 44 (3): 546–560. doi:10.1038/s41401-022-00966-8. PMC 9958013. PMID 36042291.

[2] Xuan A, Liu M, Zhang L, Lu G, Liu H, Zheng L, et al. (July 2025). "SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating the M1/M2 Macrophage Ratio and Inhibiting the MyD88/NF-χB Pathway". Pharmaceuticals. 18 (8): 1143. doi:10.3390/ph18081143. PMC 12389266. PMID 40872534.

[3] Liu M, Xuan A, Zheng L, Li D, Chen C, Liu H, et al. (December 2025). "Novel coumarin derivative SZC-6 as an allosteric activator of SIRT3 alleviates diabetic kidney disease via the SIRT3-Foxo3a signaling axis". Free Radical Biology & Medicine. 240: 29–45. doi:10.1016/j.freeradbiomed.2025.08.019. PMID 40803419.

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