SBI-797812

SBI-797812
Clinical data
Drug class	NAMPT activator
Identifiers
	IUPAC name 1-[4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)urea;
CAS Number	2237268-08-3;
PubChem CID	135222620;
ChemSpider	78316901;
ChEMBL	ChEMBL4846686;
Chemical and physical data
Formula	C19H22N4O4S
Molar mass	402.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC2CN(CC1O2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=CC=NC=C4;
	InChI InChI=1S/C19H22N4O4S/c24-19(21-11-14-7-9-20-10-8-14)22-15-1-5-18(6-2-15)28(25,26)23-12-16-3-4-17(13-23)27-16/h1-2,5-10,16-17H,3-4,11-13H2,(H2,21,22,24); Key:KTSOHNHLOLGQCY-UHFFFAOYSA-N;

SBI-797812, is a drug which acts as a selective activator of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). It increases the rate of nicotinamide mononucleotide production by NAMPT and decreases feedback inhibition by NAD+. It has been researched for application as a potential anti-aging drug.^[1]^[2]

References

^ Gardell SJ, Hopf M, Khan A, Dispagna M, Hampton Sessions E, Falter R, et al. (July 2019). "Boosting NAD⁺ with a small molecule that activates NAMPT". Nature Communications. 10 (1) 3241. Bibcode:2019NatCo..10.3241G. doi:10.1038/s41467-019-11078-z. PMC 6642140. PMID 31324777.
^ Khaidizar FD, Bessho Y, Nakahata Y (April 2021). "Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process". International Journal of Molecular Sciences. 22 (7): 3709. doi:10.3390/ijms22073709. PMC 8037941. PMID 33918226.

[1] Gardell SJ, Hopf M, Khan A, Dispagna M, Hampton Sessions E, Falter R, et al. (July 2019). "Boosting NAD⁺ with a small molecule that activates NAMPT". Nature Communications. 10 (1) 3241. Bibcode:2019NatCo..10.3241G. doi:10.1038/s41467-019-11078-z. PMC 6642140. PMID 31324777.

[2] Khaidizar FD, Bessho Y, Nakahata Y (April 2021). "Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process". International Journal of Molecular Sciences. 22 (7): 3709. doi:10.3390/ijms22073709. PMC 8037941. PMID 33918226.

[1]

[2]

See also

References