Route 666

Route 666 may refer to:

• Alberta Highway 666
• Ontario Highway 666, renumbered to 658 in 1985

• R666 road (Ireland)

• A666 road

• U.S. Route 666, renumbered in 2003 to U.S. Route 491
• Florida State Road 666
• County Route 666 (Atlantic County, New Jersey)
• Ohio State Route 666
• Pennsylvania Route 666

• Route 666 (comics), a 2002 comic book published by CrossGen Comics

• Route 666 (Helltrain album), 2006
• Route 666 (The Iron Maiden album), 2007
• Route 666 (The Hamsters album), 1995
• "Route 666", a song by God Is an Astronaut from The End of the Beginning
• "Route 666", a song by The Comsat Angels from My Mind's Eye
• "Route 666", a song by BB Tone from Natural Born Killers
• "Route 666", a song by L'Arc-en-Ciel from Real
• "Hwy 666", a song by Corey Taylor from the 2022 album CMFT

• Route 666 (film), a 2001 American horror film
• Route 666: America's Scariest Home Haunts, an Internet TV series
• "Route 666" (Married... with Children), an episode of Married... with Children
• "Route 666" (Supernatural), an episode of Supernatural
• "Route 666", a fictional funhouse ride in the 2004 film The Machinist

• Ride to Hell: Route 666, a cancelled digitally distributed spinoff of Ride to Hell: Retribution