Ricobendazole
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| Trade names | Rycoben |
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| ECHA InfoCard | 100.157.043 |
| Chemical and physical data | |
| Formula | C12H15N3O3S |
| Molar mass | 281.33 g·mol−1 |
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Ricobendazole, also known as albendazole S-oxide, is a broad-spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against nematode parasites.[1] Ricobendazole is the active sulfoxide metabolite of albendazole.[2]
Like mebendazole, ricobendazole inhibits tubulin polymerization.
Metabolic product of albendazole
Ricobendazole is produced in many species and in human liver when albendazole undergoes first-pass metabolism by the enzymes albendazole monooxygenase (sulfoxide-forming) (a cytochrome P450 oxidase) or albendazole monooxygenase (a flavin-containing monooxygenase.[3]
References
- ^ Junquera P (26 July 2015). "Ricobendazole = Albendazole Sulfoxide for Veterinary Use on Cattle, Sheep, Goats, Pig Poultry, Dogs and Cats against roundworms, tapeworms and liver flukes". Parasitipedia. Archived from the original on 4 March 2016. Retrieved 21 October 2015.
- ^ Stuchlíková LR, Matoušková P, Vokřál I, Lamka J, Szotáková B, Sečkařová A, et al. (2018). "Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites". International Journal for Parasitology: Drugs and Drug Resistance. 8 (1): 50–58. doi:10.1016/j.ijpddr.2018.01.005. PMC 6114105. PMID 29414106.
- ^ Rawden HC, Kokwaro GO, Ward SA, Edwards G (2000). "Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes". British Journal of Clinical Pharmacology. 49 (4): 313–322. doi:10.1046/j.1365-2125.2000.00170.x. PMC 2014938. PMID 10759686.