Pyruvate oxidase (CoA-acetylating)
| pyruvate oxidase (CoA-acetylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.3.6 | ||||||||
| CAS no. | 62213-57-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, pyruvate oxidase (CoA-acetylating) (EC 1.2.3.6) is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are pyruvic acid, coenzyme A, and oxygen. Its products are acetyl-CoA, carbon dioxide, and hydrogen peroxide.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyruvate:oxygen 2 - oxidoreductase (CoA-acetylating). This enzyme participates in pyruvate metabolism. It employs one cofactor, flavin adenine dinucleotide.[1]
References
- ^ a b Enzyme 1.2.3.6 at KEGG Pathway Database.
- ^ Reeves RE, Warren LG, Susskind B, Lo HS (1977). "An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252 (2): 726–31. doi:10.1016/S0021-9258(17)32778-3. PMID 13076.
- ^ Takeuchi T, Weinbach EC, Diamond LS (1975). "Pyruvate oxidase (CoA acetylating) in Entamoeba histolytica". Biochem. Biophys. Res. Commun. 65 (2): 591–6. Bibcode:1975BBRC...65..591T. doi:10.1016/S0006-291X(75)80187-2. PMID 167776.