Pyrimethamine/dapsone
| Combination of | |
|---|---|
| Pyrimethamine | Antimalarial |
| Dapsone | Antimicrobial |
| Clinical data | |
| Trade names | Maloprim |
Pyrimethamine/dapsone, sold under the brand name Maloprim, is a combination medication used to treat malaria and pneumocystis jiroveci pneumonia.[1][2] It contains a combination of pyrimethamine (Daraprim), an antimalarial, and dapsone, a sulfone. It is especially useful for preventing reactivation of latent infections in immunocompromised adults.[3] However, its use is limited by the possibility of hematologic toxicity.[3]
References
- ^ Pividal J, Viktinski V, Streat E, Schapira A (June 1992). "Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique". East African Medical Journal. 69 (6): 303–305. PMID 1505413.
- ^ "Pyrimethamine (Monograph)". Drugs.com. Retrieved 2025-09-17.
- ^ a b Aronson JK, ed. (2006). "Pyrimethamine". Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. pp. 2984–2988. doi:10.1016/B0-44-451005-2/00737-3. ISBN 978-0-444-51005-1.