Pteridine reductase
| Pteridine reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.1.33 | ||||||||
| CAS no. | 131384-61-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pteridine reductase (EC 1.5.1.33) is an enzyme that catalyzes the chemical reaction
The substrates of this enzyme are biopterin, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and two protons. Its products are tetrahydrobiopterin and oxidised NADP+.[1][2] It was isolated from the parasite Leishmania major.[3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase. Other names in common use include PTR1, and pteridine reductase 1.[4]
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1W0C, 2BF7, 2BFA, 2BFM, 2BFO, 2BFP, and 2C7V.
References
- ^ Enzyme 1.5.1.33 at KEGG Pathway Database.
- ^ Gourley DG, Schüttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN (2001). "Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites". Nat. Struct. Biol. 8 (6): 521–5. doi:10.1038/88584. PMID 11373620. S2CID 32379320.
- ^ Nare B, Hardy LW, Beverley SM (1997). "The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major". J. Biol. Chem. 272 (21): 13883–91. doi:10.1074/jbc.272.21.13883. PMID 9153248.
- ^ Fitzpatrick PF (2000). "The Aromatic Amino Acid Hydroxylases". Advances in Enzymology and Related Areas of Molecular Biology. Vol. 74. pp. 235–94. doi:10.1002/9780470123201.ch6. ISBN 978-0-470-12320-1. PMID 10800597.