Protopine 6-monooxygenase
| protopine 6-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.98 | ||||||||
| CAS no. | 128561-60-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Protopine 6-monooxygenase (EC 1.14.14.98) is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are protopine, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and oxygen. ts initial benzylisoquinoline alkaloid product is 6-hydroxyprotopine but this spontaneously forms dihydrosanguinarine.[1][2] NADP+ and water are the by-products.[3]
The systematic name of this enzyme class is protopine,NADPH:oxygen oxidoreductase (6-hydroxylating). It is also called protopine 6-hydroxylase.
References
- ^ Tanahashi, Takao; Zenk, Meinhart H. (1990). "Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis". Phytochemistry. 29 (4): 1113–1122. doi:10.1016/0031-9422(90)85414-B.
- ^ Tian, Ya; Kong, Lingzhe; Li, Qi; Wang, Yifan; Wang, Yongmiao; An, Zhoujie; Ma, Yuwei; Tian, Lixia; Duan, Baozhong; Sun, Wei; Gao, Ranran; Chen, Shilin; Xu, Zhichao (2024). "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids". Natural Product Reports. 41 (11): 1787–1810. doi:10.1039/d4np00029c. PMID 39360417.
- ^ Enzyme 1.14.14.98 at KEGG Pathway Database.