Peter Murray (immunologist)

Peter Jonathan Murray
Born (1965-08-30) August 30, 1965
Melbourne, Australia
EducationYarra Valley Grammar

Monash University, B.Sc. (Hons) University of Melbourne, PhD

Whitehead Institute, Mentor: Richard A. Young
Spouse(s)Brenda A. Schulman married 1999, Tucson, AZ
Scientific career
FieldsImmunology
Biochemistry
Cancer Research
Parasitology
Websitehttps://www.biochem.mpg.de/de/murray

Peter Jonathan Murray (born August 30, 1965 in Melbourne, Australia) is an Australian-American immunologist and biochemist. Since 2017, he has been the head of the Immunoregulation research group at the Max Planck Institute for Biochemistry in Martinsried, Germany. His research focuses on the control of immune responses by cytokines and metabolic pathways in the context of infection and cancer.[1]

Early life

Murray was born in the Melbourne suburb of Box Hill and grew up in the eastern suburbs of Croydon and Ringwood. Murray attended Yarra Valley Grammar from 1978-1983.

Education

Murray began his tertiary education in the Faculty of Arts at Monash University. After his first year studying history, he transferred to the Faculty of Science where he focused on chemistry and biochemistry. He graduated with first class honors in Biochemistry 1987 and then began a PhD at the Walter and Eliza Hall Institute, University of Melbourne in parasitology, focusing on identification, gene structure and biology Leishmania cell surface proteins.[2]

Career

Murray performed postdoctoral research in Richard A. Young's laboratory at the Whitehead Institute/Department of Biology, MIT from 1991-1998. Murray joined the Department of Infectious Diseases at St. Jude Children's Research hospital in 1998 and remained there until May, 2017 when he moved to Germany. In addition to heading the Immunoregulation research group, Murray is also an honorary professor in the Faculty of Medicine, Technische Universität München.[2] At the start of 2024, Murray has published 180 papers and has an h-index of 90.[3]

Key discoveries

Murray is best known for discoveries in the area of how cells of the immune system are controlled by cytokines and metabolic signals, especially essential amino acids such as arginine and tryptophan. Murray's group published key findings about how the central anti-inflammatory cytokine IL-10 controls activated macrophages and the regulation of signaling from the IL-6 receptor,[4][5][6] how the arginine hydrolase arginase-1 controls immune responses,[7][8][9][10][11][12] and more recently, how immune cells deploy tryptophan metabolism via IL4i1 or IDO1 to suppress oxidative cell death or ferroptosis.[13][14][15] Murray is a highly-cited researcher in immunology (Clarivate[16]). In addition, Murray has contributed numerous key research reagents and resources to the field, including the widely-used arginase-1 conditional knockoutmouse.

Murray has advocated for improved standards in research involving activated macrophages. Together with Alberto Mantovani, Thomas A. Wynn and many other collaborators and colleagues working to understand macrophage biology, Murray proposed basic experimental and reporting standards to describe the complexity of macrophage polarization in vitro and in vivo.[17][18][19] These three key papers have been collectively cited over 13,000 times.

References

  1. ^ "Peter Murray". www.biochem.mpg.de. Retrieved 2024-04-02.
  2. ^ a b "Curriculum Vitae". www.biochem.mpg.de. Retrieved 2024-04-02.
  3. ^ "Peter J. Murray". scholar.google.de. Retrieved 2024-04-02.
  4. ^ Murray, Peter J. (2005-06-14). "The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription". Proceedings of the National Academy of Sciences. 102 (24): 8686–8691. Bibcode:2005PNAS..102.8686M. doi:10.1073/pnas.0500419102. ISSN 0027-8424. PMC 1150817. PMID 15937121.
  5. ^ Lang, Roland; Pauleau, Anne-Laure; Parganas, Evan; Takahashi, Yutaka; Mages, Jörg; Ihle, James N.; Rutschman, Robert; Murray, Peter J. (June 2003). "SOCS3 regulates the plasticity of gp130 signaling". Nature Immunology. 4 (6): 546–550. doi:10.1038/ni932. ISSN 1529-2908. PMID 12754506.
  6. ^ Lang, Roland; Patel, Divyen; Morris, John J.; Rutschman, Robert L.; Murray, Peter J. (2002-09-01). "Shaping gene expression in activated and resting primary macrophages by IL-10". Journal of Immunology (Baltimore, Md.: 1950). 169 (5): 2253–2263. doi:10.4049/jimmunol.169.5.2253. ISSN 0022-1767. PMID 12193690.
  7. ^ Duque-Correa, María A.; Kühl, Anja A.; Rodriguez, Paulo C.; Zedler, Ulrike; Schommer-Leitner, Sandra; Rao, Martin; Weiner, January; Hurwitz, Robert; Qualls, Joseph E.; Kosmiadi, George A.; Murray, Peter J.; Kaufmann, Stefan H. E.; Reece, Stephen T. (2014-09-23). "Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas". Proceedings of the National Academy of Sciences of the United States of America. 111 (38): E4024–4032. Bibcode:2014PNAS..111E4024D. doi:10.1073/pnas.1408839111. ISSN 1091-6490. PMC 4183271. PMID 25201986.
  8. ^ Qualls, Joseph E.; Subramanian, Chitra; Rafi, Wasiulla; Smith, Amber M.; Balouzian, Liza; DeFreitas, Ashley A.; Shirey, Kari Ann; Reutterer, Benjamin; Kernbauer, Elisabeth; Stockinger, Silvia; Decker, Thomas; Miyairi, Isao; Vogel, Stefanie N.; Salgame, Padmini; Rock, Charles O. (2012-09-13). "Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1". Cell Host & Microbe. 12 (3): 313–323. doi:10.1016/j.chom.2012.07.012. ISSN 1934-6069. PMC 3444824. PMID 22980328.
  9. ^ Pesce, John T.; Ramalingam, Thirumalai R.; Mentink-Kane, Margaret M.; Wilson, Mark S.; El Kasmi, Karim C.; Smith, Amber M.; Thompson, Robert W.; Cheever, Allen W.; Murray, Peter J.; Wynn, Thomas A. (April 2009). "Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis". PLOS Pathogens. 5 (4) e1000371. doi:10.1371/journal.ppat.1000371. ISSN 1553-7374. PMC 2660425. PMID 19360123.
  10. ^ El Kasmi, Karim C.; Qualls, Joseph E.; Pesce, John T.; Smith, Amber M.; Thompson, Robert W.; Henao-Tamayo, Marcela; Basaraba, Randall J.; König, Till; Schleicher, Ulrike; Koo, Mi-Sun; Kaplan, Gilla; Fitzgerald, Katherine A.; Tuomanen, Elaine I.; Orme, Ian M.; Kanneganti, Thirumala-Devi (December 2008). "Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens". Nature Immunology. 9 (12): 1399–1406. doi:10.1038/ni.1671. ISSN 1529-2916. PMC 2584974. PMID 18978793.
  11. ^ Pauleau, Anne-Laure; Rutschman, Robert; Lang, Roland; Pernis, Alessandra; Watowich, Stephanie S.; Murray, Peter J. (2004-06-15). "Enhancer-mediated control of macrophage-specific arginase I expression". Journal of Immunology (Baltimore, Md.: 1950). 172 (12): 7565–7573. doi:10.4049/jimmunol.172.12.7565. ISSN 0022-1767. PMID 15187136.
  12. ^ Rutschman, R.; Lang, R.; Hesse, M.; Ihle, J. N.; Wynn, T. A.; Murray, P. J. (2001-02-15). "Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production". Journal of Immunology (Baltimore, Md.: 1950). 166 (4): 2173–2177. doi:10.4049/jimmunol.166.4.2173. ISSN 0022-1767. PMID 11160269.
  13. ^ Zeitler, Leonie; Murray, Peter J. (June 2023). "IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer". The Journal of Biological Chemistry. 299 (6) 104827. doi:10.1016/j.jbc.2023.104827. ISSN 1083-351X. PMC 10318530. PMID 37196768.
  14. ^ Fiore, Alessandra; Zeitler, Leonie; Russier, Marion; Groß, Annette; Hiller, Maria-Kathrin; Parker, Joanne L.; Stier, Luca; Köcher, Thomas; Newstead, Simon; Murray, Peter J. (2022-03-03). "Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling". Molecular Cell. 82 (5): 920–932.e7. doi:10.1016/j.molcel.2022.02.007. ISSN 1097-4164. PMC 7617904. PMID 35245456.
  15. ^ Zeitler, Leonie; Fiore, Alessandra; Meyer, Claudia; Russier, Marion; Zanella, Gaia; Suppmann, Sabine; Gargaro, Marco; Sidhu, Sachdev S.; Seshagiri, Somasekar; Ohnmacht, Caspar; Köcher, Thomas; Fallarino, Francesca; Linkermann, Andreas; Murray, Peter J. (2021-03-01). "Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism". eLife. 10 e64806. doi:10.7554/eLife.64806. ISSN 2050-084X. PMC 7946422. PMID 33646117.
  16. ^ "Clarivate - Leading Global Transformative Intelligence". February 7, 2024.
  17. ^ Murray, Peter J. (2017-02-10). "Macrophage Polarization". Annual Review of Physiology. 79: 541–566. doi:10.1146/annurev-physiol-022516-034339. ISSN 1545-1585. PMID 27813830.
  18. ^ Murray, Peter J.; Allen, Judith E.; Biswas, Subhra K.; Fisher, Edward A.; Gilroy, Derek W.; Goerdt, Sergij; Gordon, Siamon; Hamilton, John A.; Ivashkiv, Lionel B.; Lawrence, Toby; Locati, Massimo; Mantovani, Alberto; Martinez, Fernando O.; Mege, Jean-Louis; Mosser, David M. (2014-07-17). "Macrophage activation and polarization: nomenclature and experimental guidelines". Immunity. 41 (1): 14–20. doi:10.1016/j.immuni.2014.06.008. ISSN 1097-4180. PMC 4123412. PMID 25035950.
  19. ^ Murray, Peter J.; Wynn, Thomas A. (November 2011). "Protective and pathogenic functions of macrophage subsets". Nature Reviews Immunology. 11 (11): 723–737. doi:10.1038/nri3073. ISSN 1474-1741. PMC 3422549. PMID 21997792.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.