PA-915

PA-915
Identifiers
	IUPAC name 1-(7-chloro-1H-indazol-3-yl)-N-[2-(1H-imidazol-5-yl)ethyl]-5-oxopyrrolidine-3-carboxamide;
CAS Number	2305204-24-2;
PubChem CID	142550469;
Chemical and physical data
Formula	C17H17ClN6O2
Molar mass	372.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C(CN(C1=O)C2=NNC3=C2C=CC=C3Cl)C(=O)NCCC4=CN=CN4;
	InChI InChI=1S/C17H17ClN6O2/c18-13-3-1-2-12-15(13)22-23-16(12)24-8-10(6-14(24)25)17(26)20-5-4-11-7-19-9-21-11/h1-3,7,9-10H,4-6,8H2,(H,19,21)(H,20,26)(H,22,23); Key:MCXQHNLGSHUYBL-UHFFFAOYSA-N;

PA-915 is a drug used in scientific research which acts as a selective antagonist of the pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1). In animal studies it has been found to prevent the development of allodynia and shows analgesic effects against neuropathic pain,^[1] and also shows antidepressant effects.^[2]

References

^ Takasaki I, Ogashi H, Okada T, Shimodaira A, Hayakawa D, Watanabe A, et al. (January 2020). "Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain". European Journal of Medicinal Chemistry. 186 111902. doi:10.1016/j.ejmech.2019.111902. PMID 31771828.
^ Shintani Y, Hayata-Takano A, Takasaki I, Kurihara T, Miyata A, Yamano Y, et al. (September 2025). "Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models". Molecular Psychiatry. doi:10.1038/s41380-025-03209-4. PMID 40908362.