o-aminophenol oxidase
| o-Aminophenol oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.10.3.4 | ||||||||
| CAS no. | 9013-85-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
o-Aminophenol oxidase (EC 1.10.3.4, isophenoxazine synthase, o-aminophenol:O2 oxidoreductase, 2-aminophenol:O2 oxidoreductase, GriF) is an enzyme with systematic name 2-aminophenol:oxygen oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
o-Aminophenol oxidase is a flavoprotein.[4] The product phenoxazine derivative can be incorporated into natural products like grixazone and actinomycin.[5][6]
References
- ^ Nair PM, Vaidyanathan CS (March 1964). "Isophenoxazine synthase". Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects. 81 (3): 507–16. doi:10.1016/0926-6569(64)90135-x. PMID 14170322.
- ^ Nair PM, Vining LC (February 1965). "Isophenoxazine synthase apoenzyme from Pycnoporus coccineus". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation. 96 (2): 318–27. doi:10.1016/0926-6593(65)90015-9. PMID 14298835.
- ^ Subba Rao PV, Vaidyanathan CS (February 1967). "Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra". Archives of Biochemistry and Biophysics. 118 (2): 388–94. doi:10.1016/0003-9861(67)90365-7. PMID 4166439.
- ^ Enzyme 1.10.3.4 at KEGG Pathway Database.
- ^ Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S (January 2006). "A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone". The Journal of Biological Chemistry. 281 (2): 824–33. doi:10.1074/jbc.M505806200. PMID 16282322.
- ^ Barry, Clifton E.; Nayar, Parmesh G.; Begley, Tadhg P. (1989). "Phenoxazinone synthase: Mechanism for the formation of the phenoxazinone chromophore of actinomycin". Biochemistry. 28 (15): 6323–6333. doi:10.1021/bi00441a026. PMID 2477054.
External links
- O-aminophenol+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)