Nicotine blue oxidoreductase

Nicotine blue oxidoreductase
Identifiers
EC no.1.1.1.328
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Nicotine blue oxidoreductase (EC 1.1.1.328, nboR (gene)) is an enzyme with systematic name 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP+ 11-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

3,3'-bipyridine-2,2',5,5',6,6'-hexol
 
 
 
H+
 
H+
 
nicotine blue
 

The enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.[2] It is extracted from the bacterium Arthrobacter nicotinovorans.[1]

References

  1. ^ a b Mihasan M, Chiribau CB, Friedrich T, Artenie V, Brandsch R (April 2007). "An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism". Applied and Environmental Microbiology. 73 (8): 2479–85. Bibcode:2007ApEnM..73.2479M. doi:10.1128/AEM.02668-06. PMC 1855579. PMID 17293530.
  2. ^ Enzyme 1.1.1.328 at KEGG Pathway Database.