Nicotianamine synthase
| Nicotianamine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.43 | ||||||||
| CAS no. | 161515-44-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Nicotianamine synthase (EC 2.5.1.43) is an enzyme that catalyzes the chemical reaction
The enzyme converts three units of its substrate, S-adenosyl methionine, into nicotianamine and three units of 5′-methylthioadenosine as a by-product.[1][2]
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-Lmethioni ne 3-amino-3-carboxypropyltransferase. Nicotianamine is a metal-chelating molecule ubiquitous in higher plants that assists in their uptake of metals from soil.[3][4]
References
- ^ Enzyme 2.5.1.43 at KEGG Pathway Database.
- ^ Higuchi, Kyoko; Kanazawa, Kenji; Nishizawa, Naoko-Kishi; Chino, Mitsuo; Mori, Satoshi (1994). "Purification and characterization of nicotianamine synthase from Fe-deficient barley roots". Plant and Soil. 165 (2): 173–179. doi:10.1007/BF00008059.
- ^ Takahashi, Michiko; Terada, Yasuko; Nakai, Izumi; et al. (2003). "Role of Nicotianamine in the Intracellular Delivery of Metals and Plant Reproductive Development". The Plant Cell. 15 (6): 1263–1280. doi:10.1105/tpc.010256. PMC 156365. PMID 12782722.
- ^ Marschner, Horst (2012). Marschner's Mineral Nutrition of Higher Plants. London Waltham, MA: Academic Press. ISBN 978-0-12-384905-2.