NCGC00135472

NCGC00135472
Identifiers
	IUPAC name 3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide;
CAS Number	862811-76-5;
PubChem CID	7080326;
ChemSpider	5431483;
Chemical and physical data
Formula	C20H14F2N4O
Molar mass	364.356 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(N=C2N1C=CC=N2)C3=CC(=CC=C3)NC(=O)C4=CC(=C(C=C4)F)F;
	InChI InChI=1S/C20H14F2N4O/c1-12-18(25-20-23-8-3-9-26(12)20)13-4-2-5-15(10-13)24-19(27)14-6-7-16(21)17(22)11-14/h2-11H,1H3,(H,24,27); Key:YOVZCQZBMAXLPR-UHFFFAOYSA-N;

NCGC00135472 (GPR32 agonist C2A) is a chemical compound which acts as a potent and selective partial agonist of the previously orphan receptor GPR32 (DRV1/RvD1). It stimulates phagocytosis by macrophages in a similar manner to the endogenous ligand resolvin D1. NCGC00135472 was discovered by high-throughput screening, and as one of the first synthetic agonists developed for this receptor, it is hoped that the discovery of this compound will lead to the development of improved ligands which will be useful for the study of GPR32 and its functions in the body.^[1]

References

^ Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, et al. (February 2019). "Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions". Cell Chemical Biology. 26 (2): 244–254.e4. doi:10.1016/j.chembiol.2018.10.023. PMC 6405215. PMID 30554914.

[Chiang_2019-1] Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, et al. (February 2019). "Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions". Cell Chemical Biology. 26 (2): 244–254.e4. doi:10.1016/j.chembiol.2018.10.023. PMC 6405215. PMID 30554914.

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