Methylglutamate dehydrogenase

Methylglutamate dehydrogenase
Identifiers
EC no.1.5.99.5
CAS no.37217-26-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Methylglutamate dehydrogenase (EC 1.5.99.5) is an enzyme that catalyzes the chemical reaction

 
H2O
 
 
 
 
+ reduced
acceptor
 
 

The three substrates of this enzyme are N-methyl-L-glutamic acid, an electron acceptor, and water. Its products are L-glutamic acid, the corresponding reduced acceptor, and formaldehyde.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N-methyl-L-glutamate:acceptor oxidoreductase (demethylating). Other names in common use include N-methylglutamate dehydrogenase, and N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating). This enzyme participates in methane metabolism.

References

  1. ^ Enzyme 1.5.99.5 at KEGG Pathway Database.
  2. ^ Hersh LB, Stark MJ, Worthen S, Fiero MK (1972). "N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme". Arch. Biochem. Biophys. 150 (1): 219–26. doi:10.1016/0003-9861(72)90029-X. PMID 5028076.