Marcetta Y. Darensbourg

Marcetta Y. Darensbourg
Born
Marcetta Bernice York
Alma materUnion College B.S. (1963)
University of Illinois Ph.D. (1967)
SpouseDonald J. Darensbourg
Awards
Scientific career
InstitutionsVassar College (1967–1969)

Tulane University (1971–1982)

Texas A&M University (1982–present)
ThesisKinetic studies of some organolithium reactions (1967)
Doctoral advisorTheodore L. Brown

Marcetta York Darensbourg is an American inorganic chemist. She is a Distinguished Professor of Chemistry at Texas A&M University. Her research focuses on bioinorganic and organometallic chemistry, particularly synthetic models of hydrogenase enzymes and iron nitrosyl complexes. She is known for her work on metallodithiolate ligands and biomimetic catalysts relevant to hydrogen metabolism. In 2017, she was elected a member of the National Academy of Sciences.

Early life

Marcetta Bernice (York) Darensbourg was born May 4, 1942, in Artemus, Kentucky. She is the daughter of school teachers Atlas H. York and Elsie Walton York. She has an older sister, Mary Lucille York, and a younger brother, Larry Hercules York. Darensbourg attended Knox Central High School in Barbourville, Kentucky.[1] During high school, she developed an interest in science, influenced in part by a teacher, Mrs. Bolton, who taught biology, physics, and chemistry.[1] Her doctoral work focused on kinetic studies of organolithium reactions.[2]

Education

Darensbourg received a B.S. in chemistry from Union College in 1963 and a Ph.D. in inorganic chemistry from the University of Illinois under the supervision of Theodore L. Brown in 1967.[1]

Career

Darensbourg was an assistant professor at Vassar College from 1967 to 1969. From 1971 to 1982, she taught at Tulane University, where she attained the rank of professor. In 1982, she joined Texas A&M University as a professor, together with Donald J. Darensbourg, and was named Distinguished Professor in 2010.[3] Her research includes studies of hydrogenase enzymes and related metal complexes.

Darensbourg has served on the board of Inorganic Syntheses and was editor of volume 32.[4] In 2011, she was elected a fellow of the American Academy of Arts and Sciences.[5]

In 2017, she was elected a member of the National Academy of Sciences.[6]

Research

Organolithium chemistry

Darensbourg studied the kinetics and aggregation behavior of organolithium compounds, including tert-butyllithium, using spectroscopic methods such as 7Li NMR. Her work examined factors influencing dissociation and exchange processes in these systems.[7]

Metal carbonyl chemistry

Darensbourg has studied the reactivity of metal carbonyl complexes, particularly the factors governing nucleophilic attack and ligand behavior in transition metal systems. Spectroscopic studies of carbene pentacarbonyl complexes demonstrated that carbene ligands can act as strong sigma donors and pi acceptors relative to carbonyl ligands.[8] Additional studies examined how ligand environments influence the site and selectivity of nucleophilic attack in metal carbonyl systems.[9]

Hydrogenase mimics

Darensbourg has developed synthetic models of hydrogenase enzyme active sites, particularly iron- and nickel-based organometallic complexes that mimic biological hydrogen metabolism. These systems can carry out catalytic hydrogen production in the absence of the native protein environment.[10] Her work has also examined factors affecting catalytic performance, including oxygen sensitivity and mechanisms of inactivation.[11] More recent studies have explored structural variations in hydrogenase-inspired complexes, including chalcogenide-containing systems, to improve catalytic activity and tolerance to oxygen.[12]

Metallodithiolates chemistry

Darensbourg has studied metallodithiolate ligands as building blocks for transition metal complexes relevant to bioinorganic chemistry. Her work has examined how these ligands coordinate metals such as nickel, iron, and cobalt, influencing electronic structure and reactivity in catalytic systems.[13] These studies contributed to understanding metal–sulfur bonding and the design of multimetallic complexes with catalytic and biomimetic functions.[14] Related work has explored applications in catalysis and small-molecule transformations.[15] More recent work has extended these systems to studies of electronic structure and magnetic interactions in sulfur-bridged multimetallic complexes, including paramagnetic iron nitrosyl species and their coupling behavior.[16][17]

Awards

Darensbourg has received several honors for her contributions to chemistry and education, including the American Chemical Society Willard Gibbs Award,[18] the American Chemical Society Award in Organometallic Chemistry (2017),[19] and the SEC Professor of the Year award (2018).[20] She has also received teaching and mentoring awards from Texas A&M University and UCLA (2016),[21] the Kosolapoff Award from Auburn University (2018),[22] and the Eminent Scholar Award from the Texas A&M Aggie Women Network (2024).[23]

References

  1. ^ a b c "Marcetta Y. Darensbourg". Texas A&M University.
  2. ^ York, Marcetta Bernice (1967). Kinetic studies of some organolithium reactions (Thesis). OCLC 498417447.
  3. ^ "Five Science Faculty Honored as Distinguished Professors" (Press release). Texas A&M University. 6 Sep 2010. Archived from the original on 28 September 2011. Retrieved 18 July 2011.
  4. ^ Marcetta Y. Darensbourg, ed. (1998). Inorganic Syntheses, Volume 32. John Wiley & Sons. doi:10.1002/9780470132630. ISBN 9780471249214.
  5. ^ "Darensbourg Elected Fellow of American Academy of Arts and Sciences" (Press release). Texas A&M University. 19 Apr 2011.
  6. ^ "Marcetta Y. Darensbourg". National Academy of Sciences. Retrieved March 22, 2026.
  7. ^ Darensbourg, Marcetta Y.; Kimura, Bert Y.; Hartwell, George E.; Brown, Theodore Lawrence (1970-03-01). "Organometallic exchange reactions. X. Cross-association of tert-butyllithium. Kinetics of tert-butyllithium dissociation". Journal of the American Chemical Society. 92 (5): 1236–1242. doi:10.1021/ja00708a022.
  8. ^ Darensbourg, Marcetta Y.; Darensbourg, Donald J. (1970). "Spectroscopic Studies of Some Carbene Pentacarbonyl Complexes of Chromium(0) and Tungsten(0)". Inorganic Chemistry. 9 (1): 32–39. doi:10.1021/ic50083a007.
  9. ^ Darensbourg, Donald J.; Darensbourg, Marcetta Y. (1970). "Reactions of Transition Metal Carbonyls with Organolithium Compounds. II. Prediction of Nucleophilic Attack at Carbon and Resultant Stereochemistry". Inorganic Chemistry. 9 (7): 1691–694. doi:10.1021/ic50089a016.
  10. ^ Lyon, Erica J; Zhao, Xuan; Georgakaki, Irene P.; Darensbourg, Marcetta Y. (2003). "The Organometallic Active Site of [Fe]hydrogenase: Models and Entatic States". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 3683–3688. Bibcode:2003PNAS..100.3683D. doi:10.1073/pnas.0536955100. PMC 152982. PMID 12642671.
  11. ^ Tye, Jesse W.; Hall, Michael B.; Darensbourg, Marcetta Y. (2005). "Better than Platinum? Fuel Cells Energized by Enzymes". Proceedings of the National Academy of Sciences of the United States of America. 102 (47): 16911–16912. Bibcode:2005PNAS..10216911T. doi:10.1073/pnas.0508740102. PMC 1288019. PMID 16286638.
  12. ^ Yang, Xuemei; Darensbourg, Marcetta Y. (2020). "The roles of chalcogenides in O 2 protection of H 2 ase active sites". Chemical Science. 11 (35): 9366–9377. doi:10.1039/D0SC02584D. ISSN 2041-6520. PMC 8161538. PMID 34094202.
  13. ^ Pulukkody, Randara; Chupik, Rachel B.; Montalvo, Steven K.; Khan, Sarosh; Bhuvanesh, Nattamai; Lim, Soon-Mi; Darensbourg, Marcetta Y. (2017). "Toward Biocompatible Dinitrosyl Iron Complexes: Sugar-Appended Thiolates". Chemical Communications. 53 (6): 1180–1183. doi:10.1039/c6cc08659d. PMID 28058431.
  14. ^ Tiankun, Zhao; Ghosh, Pokhraj; Martinez, Zachary; Liu, Xufeng; Meng, Xianggao; Darensbourg, Marcetta Y. (2017). "Discrete Air-Stable Nickel(II)-Palladium(II) Complexes as Catalysts for Suzuki-Miyaura Reaction". Organometallics. 36 (9): 1822–1827. doi:10.1021/acs.organomet.7b00176.
  15. ^ Ghosh, Pokhraj; Quiroz, Manuel; Wang, Ning; Bhuvanesh, Nattamai; Darensbourg, Marcetta Y. (2017). "Complex of as platform for exploring cooperative heterobimetallic effects in HER electro catalysis". Dalton Transactions. 46 (17): 5617–5624. doi:10.1039/c6dt04666e. PMID 28174781.
  16. ^ Quiroz, Manuel; Lockart, Molly M.; Xue, Shan; Jones, Dakota; Guo, Yisong; Pierce, Brad S.; Dunbar, Kim R.; Hall, Michael B.; Darensbourg, Marcetta Y. (2023). "Magnetic coupling between Fe(NO) spin probe ligands through diamagnetic Ni II, Pd II and Pt II tetrathiolate bridges". Chemical Science. 14 (34): 9167–9174. doi:10.1039/D3SC01546G. PMC 10466285. PMID 37655023.
  17. ^ Sun, Ning; Liu, Lei V.; Dey, Abhishek; Villar-Acevedo, Gloria; Kovacs, Julie A.; Darensbourg, Marcetta Y.; Hodgson, Keith O.; Hedman, Britt; Solomon, Edward I. (2011-01-17). "S K-Edge X-Ray Absorption Spectroscopy and Density Functional Theory Studies of High and Low Spin {FeNO} 7 Thiolate Complexes". Inorganic Chemistry. 50 (2): 427–436. doi:10.1021/ic1006378. PMC 3130116. PMID 21158471.
  18. ^ "Willard Gibbs Award". chicagoacs.org. Retrieved 2024-04-12.
  19. ^ "2017 Recipients". American Chemical Society. Retrieved 2024-04-12.
  20. ^ "SEC Faculty Achievement Awards | SEC Academics | SEC". SECU. Retrieved 2024-04-12.
  21. ^ "College of Science Honors 2016 Award Winners – TAMU Physics & Astronomy". physics.tamu.edu. Retrieved 2024-04-12.
  22. ^ "Kosolapoff Award - Chemistry & Biochemistry - AU COSAM". www.auburn.edu. Retrieved 2024-10-16.
  23. ^ Henton, Lesley (2024-10-15). "Chemist Marcetta Darensbourg Honored With Eminent Scholar Award". Texas A&M Today. Retrieved 2024-10-16.
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